dc.contributor.author | Sanders, J | en_US |
dc.contributor.author | Cooper, JA | en_US |
dc.contributor.author | Farrar, D | en_US |
dc.contributor.author | Braithwaite, S | en_US |
dc.contributor.author | Sandhu, U | en_US |
dc.contributor.author | Mythen, MG | en_US |
dc.contributor.author | Montgomery, HE | en_US |
dc.date.accessioned | 2018-03-08T14:52:19Z | |
dc.date.available | 2017-01-04 | en_US |
dc.date.issued | 2017 | en_US |
dc.date.submitted | 2018-02-20T14:47:00.565Z | |
dc.identifier.issn | 2047-0525 | en_US |
dc.identifier.other | 10.1186/s13741-017-0057-4 | |
dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/34469 | |
dc.description | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | en_US |
dc.description.abstract | BACKGROUND: Pre-operative anaemia is associated with mortality and red blood cell (RBC) transfusion requirement after cardiac surgery. However, the effect on post-operative total morbidity burden (TMB) is unknown. We explored the effect of pre-operative anaemia on post-operative TMB. METHODS: Data were drawn from the Cardiac Post-Operative Morbidity Score (C-POMS) development study (n = 442). C-POMS describes and quantifies (0-13) TMB after cardiac surgery by noting the presence/absence of 13 morbidity domains on days 3 (D3), 5 (D5), 8 (D8) and 15 (D15). Anaemia was defined as a haemoglobin concentration below 130 g/l for men and 120 g/l for women. RESULTS: Most patients were White British (86.1%) and male (79.2%) and underwent coronary artery bypass surgery (67.4%). Participants with pre-operative anaemia (n = 137, 31.5%) were over three times more likely to receive RBC transfusion (OR 3.08, 95%CI 1.88-5.06, p < 0.001), had greater D3 and D5 TMB (5 vs 3, p < 0.0001; 3 vs 2, p < 0.0001, respectively) and remained in hospital 2 days longer (8 vs 6 days, p < 0.0001) than non-anaemic patients. Transfused patients remained in hospital 5 days longer than non-transfused patients (p < 0.0001), had higher TMB on all days (all p < 0.001) and suffered greater pulmonary, renal, GI, neurological, endocrine and ambulation morbidities (p 0.026 to <0.001). Pre-operative anaemia and RBC transfusion were independently associated with increased C-POMS score. CONCLUSIONS: Pre-operative anaemia and RBC transfusion are independently associated with increased post-operative TMB. Understanding TMB may assist in post-operative patient management to reduce morbidity. We recommend the use of the C-POMS tool as a standard outcome tool in further studies. | en_US |
dc.description.sponsorship | Professors Hugh Montgomery and Michael Mythen were supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre | en_US |
dc.format.extent | 1 - ? | en_US |
dc.language | eng | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Perioper Med (Lond) | en_US |
dc.rights | Creative Commons Attribution License | |
dc.subject | Anaemia | en_US |
dc.subject | Cardiac surgery | en_US |
dc.subject | Post-operative morbidity | en_US |
dc.subject | Red blood cell transfusion | en_US |
dc.subject | Total morbidity burden | en_US |
dc.title | Pre-operative anaemia is associated with total morbidity burden on days 3 and 5 after cardiac surgery: a cohort study. | en_US |
dc.type | Article | |
dc.rights.holder | 2017. The authors | |
dc.identifier.doi | 10.1186/s13741-017-0057-4 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/28127421 | en_US |
pubs.notes | No embargo | en_US |
pubs.publication-status | Published online | en_US |
pubs.volume | 6 | en_US |
dcterms.dateAccepted | 2017-01-04 | en_US |