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HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer

dc.contributor.authorRoss-Adams, Hen_US
dc.contributor.authorBall, Sen_US
dc.contributor.authorLawrenson, Ken_US
dc.contributor.authorHalim, Sen_US
dc.contributor.authorRussell, Ren_US
dc.contributor.authorWells, Cen_US
dc.contributor.authorStrand, SHen_US
dc.contributor.authorOrntoft, TFen_US
dc.contributor.authorLarson, Men_US
dc.contributor.authorArmasu, Sen_US
dc.contributor.authorMassie, CEen_US
dc.contributor.authorAsim, Men_US
dc.contributor.authorMortensen, MMen_US
dc.contributor.authorBorre, Men_US
dc.contributor.authorWoodfine, Ken_US
dc.contributor.authorWarren, AYen_US
dc.contributor.authorLamb, ADen_US
dc.contributor.authorKay, Jen_US
dc.contributor.authorWhitaker, Hen_US
dc.contributor.authorRamos-Montoya, Aen_US
dc.contributor.authorMurrell, Aen_US
dc.contributor.authorSorensen, KDen_US
dc.contributor.authorFridley, BLen_US
dc.contributor.authorGoode, ELen_US
dc.contributor.authorGayther, SAen_US
dc.contributor.authorMasters, Jen_US
dc.contributor.authorNeal, DEen_US
dc.contributor.authorMills, IGen_US
dc.date.accessioned2018-02-23T14:49:02Z
dc.date.available2016-09-26en_US
dc.date.issued2016-11-15en_US
dc.date.submitted2018-02-20T11:21:33.594Z
dc.identifier.other10.18632/oncotarget
dc.identifier.urihttp://qmro.qmul.ac.uk/xmlui/handle/123456789/33483
dc.description.sponsorshipWe acknowledge the support of the National Cancer Research Prostate Cancer: Mechanisms of Progression and Treatment (ProMPT) collaborative (grant code G0500966/75466), which has funded tissue and urine collections in Cambridge, as well as the Human Research Tissue bank, which is supported by the NIHR Cambridge Biomedical Research Centre. We acknowledge the support of The University of Cambridge, Cancer Research UK and Hutchison Whampoa Limited, and the support of Cancer Research UK Cambridge Institute Genomics and Bioinformatics core facilities. We thank Dr Thorunn Rafnar for helpful discussions and critical review of the manuscript, and Dr Gerhart Ryffel for his kind gift of the HNF1B plasmid. This work was funded by a CRUK program grant awarded to DEN. HR-A and SB were supported by EU Framework Programme 7 grant 202059 (ProMark; http://www.promark-fp7.eu/). The Aarhus Prostate Cancer study is supported by the Danish Strategic Research Council and The Danish Cancer Society. This work was in part supported by the NIH grants R01 CA122443 and P30-CA13083 to ELG and P50-CA136393 to Mayo Clinic SPORE Ovarian Cancer, to ELG. I.G.M. is an Associate Professor at Queen’s University Belfast and funded through the PCUK/Movember Centre of Excellence for Prostate Cancer Researchen_US
dc.format.extent74734 - 74746en_US
dc.language.isoenen_US
dc.relation.ispartofONCOTARGETen_US
dc.rightsCreative Commons Attribution License
dc.subjectHNF1Ben_US
dc.subjecteQTLen_US
dc.subjectprostateen_US
dc.subjectovarianen_US
dc.subjectcanceren_US
dc.titleHNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian canceren_US
dc.typeArticle
dc.rights.holder2017. The authors
dc.identifier.doi10.18632/oncotarget.12543en_US
pubs.author-urlhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000389632800025&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6aen_US
pubs.issue46en_US
pubs.notesNo embargoen_US
pubs.publication-statusPublisheden_US
pubs.volume7en_US


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