Browsing Centre for Cancer Prevention by Subject "Databases, Genetic"
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Parkinson's disease in GTP cyclohydrolase 1 mutation carriers.
(2014-09)GTP cyclohydrolase 1, encoded by the GCH1 gene, is an essential enzyme for dopamine production in nigrostriatal cells. Loss-of-function mutations in GCH1 result in severe reduction of dopamine synthesis in nigrostriatal ...