Browsing Centre for Environmental and Preventive Medicine (CEPM) by Subject "GBA"

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    • Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts. 

      Iwaki, H; Blauwendraat, C; Leonard, HL; Kim, JJ; Liu, G; Maple-Grødem, J; Corvol, J-C; Pihlstrøm, L; van Nimwegen, M; Hutten, SJ (2019-12)
      BACKGROUND: Several reports have identified different patterns of Parkinson's disease progression in individuals carrying missense variants in GBA or LRRK2 genes. The overall contribution of genetic factors to the severity ...

    • The prodromes of Parkinson's disease. 

      NOYCE, AJ; Rees, R; Schrag, A (Wiley, 2018-11-17)
      Whilst the diagnosis of Parkinson’s disease (PD) relies on the motor triad of bradyki-nesia, rigidity and tremor, the underlying pathological process starts many years be-fore these signs are overt. In this prodromal phase ...