Browsing Centre for Environmental and Preventive Medicine (CEPM) by Author "Voak, AA"
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Evaluating aziridinyl nitrobenzamide compounds as leishmanicidal prodrugs
Voak, AA; Seifert, K; Helsby, NA; WILKINSON, SR (2014-01)Many of the nitroaromatic agents used in medicine function as prodrugs and must undergo activation before exerting their toxic effects. In most cases this is catalysed by FMN-dependent type I nitroreductases (NTRs), a class ...