Browsing Centre for Environmental and Preventive Medicine (CEPM) by Author "Old, RW"
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Prenatal maternal plasma DNA screening for cystic fibrosis: A computer modelling study of screening performance.
Old, RW; Bestwick, JP; Wald, NJ (2017)Background: Prenatal cystic fibrosis (CF) screening is currently based on determining the carrier status of both parents. We propose a new method based only on the analysis of DNA in maternal plasma. Methods: The method ... -
A simple method to allow for guanine-cytosine amplification error in prenatal DNA screening for trisomy 18
Wald, NJ; Bestwick, JP; Lau, KW; Huttly, WJ; Ke, W; Cheng, R; Old, RW (2019-09) -
Specifying a Gold Standard for the Validation of Fetal Fraction Estimation in Prenatal Screening.
Wald, NJ; Lau, KW; Bestwick, JP; Old, RW; Huttly, WJ; Cheng, R (2018-09)BACKGROUND: An estimate of fetal fraction (FF) is needed for DNA-based screening for trisomy 21 and other aneuploidies, but there is no gold standard to validate FF measurement methods. We specify a gold standard and use ...