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CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits.
(2017-09-29)
There are few examples of robust associations between rare copy number variants (CNVs) and complex continuous human traits. Here we present a large-scale CNV association meta-analysis on anthropometric traits in up to ...
Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients
(Springer Nature, 2018-05-25)
Methotrexate (MTX) monotherapy is a common first treatment for rheumatoid arthritis (RA), but many patients do not respond adequately. In order to identify genetic predictors of response, we have combined data from two ...
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
(Oxford University Press, 2018-09-04)
More than one in three adults worldwide is either overweight or obese. Epidemiological studies indicate that the location
and distribution of excess fat, rather than general adiposity, are more informative for predicting ...
Foam cell formation: A new target for fighting atherosclerosis and cardiovascular disease.
(2019-01)
During atherosclerosis, the gradual accumulation of lipids into the subendothelial space of damaged arteries results in several lipid modification processes followed by macrophage uptake in the arterial wall. The way in ...