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Now showing items 1061-1070 of 1076
Primary Results From MATCH: A Randomised Controlled Trial in Primary Aldosteronism
(The Endocrine Society, 2021-05-03)
Cardiolipin oxidized by ROS from complex II acts as a target of gasdermin D to drive mitochondrial pore and heart dysfunction in endotoxemia.
(Cell Press, 2024-05-15)
Cardiac dysfunction, an early complication of endotoxemia, is the major cause of death in intensive care units. No specific therapy is available at present for this cardiac dysfunction. Here, we show that the N-terminal ...
Epigenomic insights into common human disease pathology
(Springer Science and Business Media LLC, 2024-04-11)
The epigenome—the chemical modifications and chromatin-related packaging of the genome—enables the same genetic template to be activated or repressed in different cellular settings. This multi-layered mechanism facilitates ...
A new test for trait mean and variance detects unreported loci for blood-pressure variation.
(Elsevier, 2024-04-12)
Variability in quantitative traits has clinical, ecological, and evolutionary significance. Most genetic variants identified for complex quantitative traits have only a detectable effect on the mean of trait. We have ...