Browsing Centre for Clinical Pharmacology by Subject "genomics"
Now showing items 1-4 of 4
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Opportunities and Challenges for Molecular Understanding of Ciliopathies-The 100,000 Genomes Project.
(2019)Cilia are highly specialized cellular organelles that serve multiple functions in human development and health. Their central importance in the body is demonstrated by the occurrence of a diverse range of developmental ... -
Reaching the End-Game for GWAS: Machine Learning Approaches for the Prioritization of Complex Disease Loci.
(Frontiers Media, 2020-04-25)Genome-wide association studies (GWAS) have revealed thousands of genetic loci that underpin the complex biology of many human traits. However, the strength of GWAS - the ability to detect genetic association by linkage ... -
Use of Genomics to Develop Novel Therapeutics and Personalize Hypertension Therapy.
(2024-04)Hypertension is a prevalent public health problem, contributing to >10 million deaths annually. Though multiple therapeutics exist, many patients suffer from treatment-resistant hypertension or try several medications ...