Browsing Centre for Clinical Pharmacology by Subject "genome-wide association study"
Now showing items 1-13 of 13
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Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval.
(Elsevier, 2020-04-29)Sudden cardiac death is responsible for half of all deaths from cardiovascular disease. The analysis of the electrophysiological substrate for arrhythmias is crucial for optimal risk stratification. A prolonged T-peak-to-Tend ... -
Genetic and Molecular Aspects of Hypertension
(2015-03-13) -
Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus
(Wolters Kluwer Health, Inc. on behalf of the American Heart Association,, 2020-08-13) -
Influence of Genetic Variation in PDE3A on Endothelial Function and Stroke
(Wolters Kluwer Health, on behalf of the American Heart Association, Inc., 2019-12-23)We aimed to characterize the genetics of endothelial function and how this influences risk for cardiovascular diseases such as ischemic stroke. We integrated genetic data from a study of ultrasound flow-mediated dilatation ... -
An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins
(Nature Research (part of Springer Nature), 2014-12-12)DNA methylation has a great potential for understanding the aetiology of common complex traits such as Type 2 diabetes (T2D). Here we perform genome-wide methylated DNA immunoprecipitation sequencing (MeDIP-seq) in ... -
Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.
(Oxford University Press, 2019-01-29)An individual's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions ... -
Multiancestry Study of Gene-Lifestyle Interactions for Cardiovascular Traits in 610 475 Individuals From 124 Cohorts Design and Rationale
(American Heart Association, Inc., 2017-06-15)Background— Several consortia have pursued genome-wide association studies for identifying novel genetic loci for blood pressure, lipids, hypertension, etc. They demonstrated the power of collaborative research through ... -
Reaching the End-Game for GWAS: Machine Learning Approaches for the Prioritization of Complex Disease Loci.
(Frontiers Media, 2020-04-25)Genome-wide association studies (GWAS) have revealed thousands of genetic loci that underpin the complex biology of many human traits. However, the strength of GWAS - the ability to detect genetic association by linkage ...