Browsing Centre for Clinical Pharmacology by Subject "Multifactorial Inheritance"
Now showing items 1-3 of 3
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Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups.
(Springer Nature, 2023-06-02)We assess performance and limitations of polygenic risk scores (PRSs) for multiple blood pressure (BP) phenotypes in diverse population groups. We compare "clumping-and-thresholding" (PRSice2) and LD-based (LDPred2) methods ... -
Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia.
(2018-11-23)The epidemiologic link between schizophrenia (SCZ) and type 2 diabetes (T2D) remains poorly understood. Here, we investigate the presence and extent of a shared genetic background between SCZ and T2D using genome-wide ... -
Use of Genomics to Develop Novel Therapeutics and Personalize Hypertension Therapy.
(2024-04)Hypertension is a prevalent public health problem, contributing to >10 million deaths annually. Though multiple therapeutics exist, many patients suffer from treatment-resistant hypertension or try several medications ...