Browsing Centre for Clinical Pharmacology by Subject "Genomics"
Now showing items 1-5 of 5
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Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing.
(2017-01-30)BACKGROUND: Whole-exome sequencing (WES) has been successful in identifying genes that cause familial Parkinson's disease (PD). However, until now this approach has not been deployed to study large cohorts of unrelated ... -
Improving prenatal diagnosis through standards and aggregation.
(2024-04)Advances in sequencing and imaging technologies enable enhanced assessment in the prenatal space, with a goal to diagnose and predict the natural history of disease, to direct targeted therapies, and to implement clinical ... -
Use of Genomics to Develop Novel Therapeutics and Personalize Hypertension Therapy.
(2024-04)Hypertension is a prevalent public health problem, contributing to >10 million deaths annually. Though multiple therapeutics exist, many patients suffer from treatment-resistant hypertension or try several medications ...