Browsing Centre for Clinical Pharmacology by Subject "Genome-Wide Association Study"
Now showing items 1-16 of 16
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Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease.
(2017-05-26)BACKGROUND: Plasminogen activator inhibitor type 1 (PAI-1) plays an essential role in the fibrinolysis system and thrombosis. Population studies have reported that blood PAI-1 levels are associated with increased risk of ... -
CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits.
(2017-09-29)There are few examples of robust associations between rare copy number variants (CNVs) and complex continuous human traits. Here we present a large-scale CNV association meta-analysis on anthropometric traits in up to ... -
Cohort-specific imputation of gene expression improves prediction of warfarin dose for African Americans.
(2017-11-24)BACKGROUND: Genome-wide association studies are useful for discovering genotype-phenotype associations but are limited because they require large cohorts to identify a signal, which can be population-specific. Mapping ... -
Evaluating the glucose raising effect of established loci via a genetic risk score.
(2017)Recent genome-wide association studies have identified several single nucleotide polymorphisms (SNPs) associated with glucose levels. We tested the hypothesis here whether the cumulative effect of glucose raising SNPs, ... -
Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups.
(Springer Nature, 2023-06-02)We assess performance and limitations of polygenic risk scores (PRSs) for multiple blood pressure (BP) phenotypes in diverse population groups. We compare "clumping-and-thresholding" (PRSice2) and LD-based (LDPred2) methods ... -
Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia.
(2018-11-23)The epidemiologic link between schizophrenia (SCZ) and type 2 diabetes (T2D) remains poorly understood. Here, we investigate the presence and extent of a shared genetic background between SCZ and T2D using genome-wide ... -
Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease.
(2023-03-14)The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry ... -
GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.
(2023-09)Conventional measurements of fasting and postprandial blood glucose levels investigated in genome-wide association studies (GWAS) cannot capture the effects of DNA variability on 'around the clock' glucoregulatory processes. ... -
Height, Autoimmune Thyroid Disease, and Thyroid Cancer: A Mendelian Randomization Study.
(2023-12)Background: Increased height has been associated with increased risk of hypothyroidism or thyroid cancer in epidemiological studies. However, the potential causal association between height and hypothyroidism or thyroid ... -
Identification and analysis of individuals who deviate from their genetically-predicted phenotype.
(2023-09)Findings from genome-wide association studies have facilitated the generation of genetic predictors for many common human phenotypes. Stratifying individuals misaligned to a genetic predictor based on common variants may ... -
NeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases.
(2017-09)Genetics has proven to be a powerful approach in neurodegenerative diseases research, resulting in the identification of numerous causal and risk variants. Previously, we introduced the NeuroX Illumina genotyping array, a ... -
Radiographic endophenotyping in hip osteoarthritis improves the precision of genetic association analysis.
(2017-07)OBJECTIVE: Osteoarthritis (OA) has a strong genetic component but the success of previous genome-wide association studies (GWAS) has been restricted due to insufficient sample sizes and phenotype heterogeneity. Our aim was ... -
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
(Nature Research, 2021-01-05)Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in ... -
SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function.
(2017-03)Genome-wide association studies have identified >50 common variants associated with kidney function, but these variants do not fully explain the variation in eGFR. We performed a two-stage meta-analysis of associations ... -
Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system.
(2018-05-16)Impaired capacity to increase heart rate (HR) during exercise (ΔHRex), and a reduced rate of recovery post-exercise (ΔHRrec) are associated with higher cardiovascular mortality rates. Currently, the genetic basis of both ... -
Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility.
(2021)Epidemiological and genetic studies on COVID-19 are currently hindered by inconsistent and limited testing policies to confirm SARS-CoV-2 infection. Recently, it was shown that it is possible to predict COVID-19 cases using ...