Browsing Centre for Clinical Pharmacology by Subject "Gene Expression Regulation"
Now showing items 1-3 of 3
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A DNA methylation signature in the stress driver gene Fkbp5 indicates a neuropathic component in chronic pain.
(2023-09-30)BACKGROUND: Epigenetic changes can bring insight into gene regulatory mechanisms associated with disease pathogenicity, including chronicity and increased vulnerability. To date, we are yet to identify genes sensitive to ... -
A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells.
(2017-03-23)Individual human epidermal cells differ in their self-renewal ability. To uncover the molecular basis for this heterogeneity, we performed genome-wide pooled RNA interference screens and identified genes conferring a clonal ... -
Nox1/Ref-1-mediated activation of CREB promotes Gremlin1-driven endothelial cell proliferation and migration.
(2019-04)Pulmonary arterial hypertension (PAH) is a complex degenerative disorder marked by aberrant vascular remodeling associated with hyperproliferation and migration of endothelial cells (ECs). Previous reports implicated bone ...