Browsing Centre for Clinical Pharmacology by Subject "Gene Expression"
Now showing items 1-4 of 4
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Cohort-specific imputation of gene expression improves prediction of warfarin dose for African Americans.
(2017-11-24)BACKGROUND: Genome-wide association studies are useful for discovering genotype-phenotype associations but are limited because they require large cohorts to identify a signal, which can be population-specific. Mapping ... -
A crowdsourced analysis to identify ab initio molecular signatures predictive of susceptibility to viral infection.
(Springer Nature, 2018-10-24)The response to respiratory viruses varies substantially between individuals, and there are currently no known molecular predictors from the early stages of infection. Here we conduct a community-based analysis to determine ... -
Platelets Independently Recruit into Asthmatic Lungs and Models of Allergic Inflammation via CCR3.
(2021-05)Platelet activation and pulmonary recruitment occur in patients with asthma and in animal models of allergic asthma, in which leukocyte infiltration, airway remodeling, and hyperresponsiveness are suppressed by experimental ... -
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
(Nature Research, 2021-01-05)Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in ...