Browsing Centre for Clinical Pharmacology by Subject "GWAS"
Now showing items 1-9 of 9
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Emerging applications of genome-editing technology to examine functionality of GWAS-associated variants for complex traits.
(2018-07-01)Over the last decade, genome-wide association studies (GWAS) have propelled the discovery of thousands of loci associated with complex diseases. The focus is now turning toward the function of these association signals, ... -
Integration of genetic fine-mapping and multi-omics data reveals candidate effector genes for hypertension.
(2023-09-01)Genome-wide association studies of blood pressure (BP) have identified >1,000 loci, but the effector genes and biological pathways at these loci are mostly unknown. Using published association summary statistics, we conducted ... -
The role of resistance to inhibitors of cholinesterase 8b in the control of heart rate.
(American Physiological Society, 2021-03-15)We have assessed the role of ric-b8 in the control of heart rate after the gene was implicated in a recent genome wide association study in resting heart rate. We developed a novel murine model in which it was possible to ...