Browsing Centre for Clinical Pharmacology by Author "Yengo, L"
Now showing items 1-18 of 18
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Defining the role of common variation in the genomic and biological architecture of adult human height
Wood, AR; Esko, T; Yang, J; Vedantam, S; Pers, TH; Gustafsson, S; Chun, AY; Estrada, K; Luan, J; Kutalik, Z (2014-11) -
Directional dominance on stature and cognition in diverse human populations
Joshi, PK; Esko, T; Mattsson, H; Eklund, N; Gandin, I; Nutile, T; Jackson, AU; Schurmann, C; Smith, AV; Zhang, W (2015-07-23) -
The genetic architecture of type 2 diabetes
Fuchsberger, C; Flannick, J; Teslovich, TM; Mahajan, A; Agarwala, V; Gaulton, KJ; Ma, C; Fontanillas, P; Moutsianas, L; McCarthy, DJ (2016-08-04) -
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Pattaro, C; Teumer, A; Gorski, M; Chu, AY; Li, M; Mijatovic, V; Garnaas, M; Tin, A; Sorice, R; Li, Y (2016-01) -
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
Gaulton, KJ; Ferreira, T; Lee, Y; Raimondo, A; Maegi, R; Reschen, ME; Mahajan, A; Locke, A; Rayner, NW; Robertson, N (2015-12) -
Genetic studies of body mass index yield new insights for obesity biology
Locke, AE; Kahali, B; Berndt, SI; Justice, AE; Pers, TH; Day, FR; Powell, C; Vedantam, S; Buchkovich, ML; Yang, J (2015-02-12) -
Genome-wide analysis identifies 12 loci influencing human reproductive behavior
Barban, N; Jansen, R; de Vlaming, R; Vaez, A; Mandemakers, JJ; Tropf, FC; Shen, X; Wilson, JF; Chasman, DI; Nolte, IM (2016-12) -
Genome-wide CRISPR screening of chondrocyte maturation newly implicates genes in skeletal growth and height-associated GWAS loci.
Baronas, JM; Bartell, E; Eliasen, A; Doench, JG; Yengo, L; Vedantam, S; Marouli, E; GIANT Consortium; Kronenberg, HM; Hirschhorn, JN (2023-05-10)Alterations in the growth and maturation of chondrocytes can lead to variation in human height, including monogenic disorders of skeletal growth. We aimed to identify genes and pathways relevant to human growth by pairing ... -
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
Justice, AE; Winkler, TW; Feitosa, MF; Graff, M; Fisher, VA; Young, K; Barata, L; Deng, X; Czajkowski, J; Hadley, D (2017-04-26) -
Identification and analysis of individuals who deviate from their genetically-predicted phenotype.
Hawkes, G; Yengo, L; Vedantam, S; Marouli, E; Beaumont, RN; GIANT Consortium; Tyrrell, J; Weedon, MN; Hirschhorn, J; Frayling, TM (2023-09)Findings from genome-wide association studies have facilitated the generation of genetic predictors for many common human phenotypes. Stratifying individuals misaligned to a genetic predictor based on common variants may ... -
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (vol 11, e1005378, 2015)
Winkler, TW; Justice, AE; Graff, M; Barata, L; Feitosa, MF; Chu, S; Czajkowski, J; Esko, T; Fall, T; Kilpelainen, TO (2016-06) -
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
Pulit, SL; Stoneman, C; Morris, AP; Wood, AR; Glastonbury, CA; Tyrrell, J; Yengo, L; Ferreira, T; Marouli, E; Ji, Y (Oxford University Press, 2018-09-04)More than one in three adults worldwide is either overweight or obese. Epidemiological studies indicate that the location and distribution of excess fat, rather than general adiposity, are more informative for predicting ... -
New genetic loci link adipose and insulin biology to body fat distribution
Shungin, D; Winkler, TW; Croteau-Chonka, DC; Ferreira, T; Lockes, AE; Maegi, R; Strawbridge, RJ; Pers, TH; Fischer, K; Justice, AE (2015-02-12) -
Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
Lagou, V; Mägi, R; Hottenga, J-J; Grallert, H; Perry, JRB; Bouatia-Naji, N; Marullo, L; Rybin, D; Jansen, R; Min, JL (2021-02-08)Correction to: Nature Communications https://doi.org/10.1038/s41467-020-19366-9, published online 5 January 2021. The original version of this Article contained an error in Fig. 2, in which panels a and b were inadvertently ... -
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
Mahajan, A; Wessel, J; Willems, SM; Zhao, W; Robertson, NR; Chu, AY; Gan, W; Kitajima, H; Taliun, D; Rayner, NW (Nature Research (part of Springer Nature), 2018-04-09)We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10−7); of these, 16 map outside known risk-associated ... -
A saturated map of common genetic variants associated with human height
Yengo, L; Vedantam, S; Marouli, E; Sidorenko, J; Bartell, E; Sakaue, S; Graff, M; Eliasen, AU; Jiang, Y; Raghavan, S (2022) -
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
Lagou, V; Mägi, R; Hottenga, J-J; Grallert, H; Perry, JRB; Bouatia-Naji, N; Marullo, L; Rybin, D; Jansen, R; Min, JL (Nature Research, 2021-01-05)Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in ... -
The trans-ancestral genomic architecture of glycemic traits.
Chen, J; Spracklen, CN; Marenne, G; Varshney, A; Corbin, LJ; Luan, J; Willems, SM; Wu, Y; Zhang, X; Horikoshi, M (2021-05-31)Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide ...