Browsing Centre for Clinical Pharmacology by Author "Xia, Y"
Now showing items 1-6 of 6
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Contribution of Heritability and Epigenetic Factors to Skeletal Muscle Mass Variation in United Kingdom Twins
Livshits, G; Gao, F; Malkin, I; Needhamsen, M; Xia, Y; Yuan, W; Bell, CG; Ward, K; Liu, Y; Wang, J (2016-06) -
DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases
Wielscher, M; Mandaviya, PR; Kuehnel, B; Joehanes, R; Mustafa, R; Robinson, O; Zhang, Y; Bodinier, B; Walton, E; Mishra, PP (2022) -
The Genomic Loci of Specific Human tRNA Genes Exhibit Ageing-Related DNA Hypermethylation
Acton, R; Yuan, W; Gao, F; Xia, Y; Bourne, E; Wozniak, E; Bell, J; Lillycrop, K; Wang, J; Dennison, E (2019-12-10)Abstract Understanding how the epigenome deteriorates with age and subsequently impacts on biological function may bring unique insights to ageing-related disease mechanisms. As a central cellular apparatus, tRNAs are ... -
An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins
Yuan, W; Xia, Y; Bell, CG; Yet, I; Ferreira, T; Ward, KJ; Gao, F; Loomis, AK; Hyde, CL; Wu, H (Nature Research (part of Springer Nature), 2014-12-12)DNA methylation has a great potential for understanding the aetiology of common complex traits such as Type 2 diabetes (T2D). Here we perform genome-wide methylated DNA immunoprecipitation sequencing (MeDIP-seq) in ... -
Melamine Impairs Renal and Vascular Function in Rats.
Tian, XY; Wong, WT; Lau, CW; Wang, Y-X; Cheang, WS; Liu, J; Lu, Y; Huang, H; Xia, Y; Chen, ZY (2016-06-21)Melamine incident, linked to nephrotoxicity and kidney stone in infants previously exposed to melamine-contaminated milk products, was unprecedentedly grave in China in 2008 as little was known about the mechanistic process ... -
Novel regional age-associated DNA methylation changes within human common disease-associated loci
Bell, CG; Xia, Y; Yuan, W; Gao, F; Ward, K; Roos, L; Mangino, M; Hysi, PG; Bell, J; Wang, J (2016-09-23)