Browsing Centre for Clinical Pharmacology by Author "Tyrrell, J"
Now showing items 1-7 of 7
-
CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits.
Macé, A; Tuke, MA; Deelen, P; Kristiansson, K; Mattsson, H; Nõukas, M; Sapkota, Y; Schick, U; Porcu, E; Rüeger, S (2017-09-29)There are few examples of robust associations between rare copy number variants (CNVs) and complex continuous human traits. Here we present a large-scale CNV association meta-analysis on anthropometric traits in up to ... -
Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use
Brazel, DM; Jiang, Y; Hughey, JM; Turcot, V; Zhan, X; Gong, J; Batini, C; Weissenkampen, JD; Liu, M; Barnes, DR (2019-06-01) -
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
Justice, AE; Winkler, TW; Feitosa, MF; Graff, M; Fisher, VA; Young, K; Barata, L; Deng, X; Czajkowski, J; Hadley, D (2017-04-26) -
Identification and analysis of individuals who deviate from their genetically-predicted phenotype.
Hawkes, G; Yengo, L; Vedantam, S; Marouli, E; Beaumont, RN; GIANT Consortium; Tyrrell, J; Weedon, MN; Hirschhorn, J; Frayling, TM (2023-09)Findings from genome-wide association studies have facilitated the generation of genetic predictors for many common human phenotypes. Stratifying individuals misaligned to a genetic predictor based on common variants may ... -
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
Pulit, SL; Stoneman, C; Morris, AP; Wood, AR; Glastonbury, CA; Tyrrell, J; Yengo, L; Ferreira, T; Marouli, E; Ji, Y (Oxford University Press, 2018-09-04)More than one in three adults worldwide is either overweight or obese. Epidemiological studies indicate that the location and distribution of excess fat, rather than general adiposity, are more informative for predicting ... -
Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.
Erzurumluoglu, AM; Liu, M; Jackson, VE; Barnes, DR; Datta, G; Melbourne, CA; Young, R; Batini, C; Surendran, P; Jiang, T (Springer Nature, 2019-01-07)Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with smoking ... -
Quantifying the extent to which index event biases influence large genetic association studies
Yaghootkar, H; Bancks, MP; Jones, SE; McDaid, A; Beaumont, R; Donnelly, L; Wood, AR; Campbell, A; Tyrrell, J; Hocking, LJ (2017-03-01)