Browsing Centre for Clinical Pharmacology by Author "Tragante, V"
Now showing items 1-15 of 15
-
52 Genetic Loci Influencing Myocardial Mass
van der Harst, P; van Setten, J; Verweij, N; Vogler, G; Franke, L; Maurano, MT; Wang, X; Leach, IM; Eijgelsheim, M; Sotoodehnia, N (2016-09-27) -
Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events A GENIUS-CHD Study of Individual Participant Data
Patel, RS; Schmidt, AF; Tragante, V; McCubrey, RO; Holmes, MV; Howe, LJ; Direk, K; Akerblom, A; Leander, K; Virani, SS (2019-04) -
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
Surendran, P; Feofanova, EV; Lahrouchi, N; Ntalla, I; Karthikeyan, S; Cook, J; Chen, L; Mifsud, B; Yao, C; Kraja, AT (2020) -
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals (vol 52, pg 1314, 2020)
Surendran, P; Feofanova, EV; Lahrouchi, N; Ntalla, I; Karthikeyan, S; Cook, J; Chen, L; Mifsud, B; Yao, C; Kraja, AT (2021) -
Druggability of Coronary Artery Disease Risk Loci
Tragante, V; Hemerich, D; Alshabeeb, M; Braenne, I; Lempiaeinen, H; Patel, RS; den Ruijter, HM; Barnes, MR; Moore, JH; Schunkert, H (American Heart Association, Inc., 2018-08-13)Background: Genome-wide association studies have identified multiple loci associated with coronary artery disease and myocardial infarction, but only a few of these loci are current targets for on-market medications. To ... -
Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use
Brazel, DM; Jiang, Y; Hughey, JM; Turcot, V; Zhan, X; Gong, J; Batini, C; Weissenkampen, JD; Liu, M; Barnes, DR (2019-06-01) -
Fine mapping of blood pressure-related variants on epigenetic human data
Hemerich, D; Tragante, V; Harakalova, M; Mokry, M; Kerstens, H; Munroe, PB; Asselbergs, FW (2016-04) -
Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci
Tragante, V; Barnes, MR; Ganesh, SK; Lanktree, MB; Guo, W; Franceschini, N; Smith, EN; Johnson, T; Holmes, MV; Padmanabhan, S (2014-03-06) -
Genome-wide analysis identifies 12 loci influencing human reproductive behavior
Barban, N; Jansen, R; de Vlaming, R; Vaez, A; Mandemakers, JJ; Tropf, FC; Shen, X; Wilson, JF; Chasman, DI; Nolte, IM (2016-12) -
Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk.
Brænne, I; Zeng, L; Willenborg, C; Tragante, V; Kessler, T; CARDIoGRAM Consortium; CARDIoGRAMplusC4D Consortium; Willer, CJ; Laakso, M; Wallentin, L (2017)Glatiramer acetate is used therapeutically in multiple sclerosis but also known for adverse effects including elevated coronary artery disease (CAD) risk. The mechanisms underlying the cardiovascular side effects of the ... -
Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.
Erzurumluoglu, AM; Liu, M; Jackson, VE; Barnes, DR; Datta, G; Melbourne, CA; Young, R; Batini, C; Surendran, P; Jiang, T (Springer Nature, 2019-01-07)Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with smoking ... -
New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475000 Individuals
Kraja, AT; Cook, JP; Warren, HR; Surendran, P; Liu, C; Evangelou, E; Manning, AK; Grarup, N; Drenos, F; Sim, X (American Heart Association, 2017-10-13)Background— Genome-wide association studies have recently identified >400 loci that harbor DNA sequence variants that influence blood pressure (BP). Our earlier studies identified and validated 56 single nucleotide variants ... -
Subsequent Event Risk in Individuals With Established Coronary Heart Disease Design and Rationale of the GENIUS-CHD Consortium
Patel, RS; Tragante, V; Schmidt, AF; McCubrey, RO; Holmes, MV; Howe, LJ; Direk, K; Akerblom, A; Leander, K; Virani, SS (2019-04) -
Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation
Ng, N; Willems, SM; Fernandez, J; Fine, RS; Wheeler, E; Wessel, J; Kitajima, H; Marenne, G; Rundle, JK; Sim, X (2019-10-15) -
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
Surendran, P; Drenos, F; Young, R; Warren, H; Cook, JP; Manning, AK; Grarup, N; Sim, X; Barnes, DR; Witkowska, K (2016-10)