Browsing Centre for Clinical Pharmacology by Author "Psaty, BM"
Now showing items 1-20 of 53
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52 Genetic Loci Influencing Myocardial Mass
van der Harst, P; van Setten, J; Verweij, N; Vogler, G; Franke, L; Maurano, MT; Wang, X; Leach, IM; Eijgelsheim, M; Sotoodehnia, N (2016-09-27) -
Adverse Cardiovascular Outcomes and Antihypertensive Treatment: A Genome-Wide Interaction Meta-Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies
McDonough, CW; Warren, HR; Jack, JR; Motsinger-Reif, AA; Armstrong, ND; Bis, JC; House, JS; Singh, S; El Rouby, NM; Gong, Y (2021) -
Association of Birth Weight With Type 2 Diabetes and Glycemic Traits A Mendelian Randomization Study
Huang, T; Wang, T; Zheng, Y; Ellervik, C; Li, X; Gao, M; Fang, Z; Chai, J-F; Ahluwalia, TVS; Wang, Y (2019-09)Importance: Observational studies have shown associations of birth weight with type 2 diabetes (T2D) and glycemic traits, but it remains unclear whether these associations represent causal associations. Objective: To ... -
Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval
Lin, H; van Setten, J; Smith, AV; Bihlmeyer, NA; Warren, HR; Brody, JA; Radmanesh, F; Hall, L; Grarup, N; Mueller-Nurasyid, M (2018-05) -
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction
Sotoodehnia, N; Isaacs, A; de Bakker, PIW; Dorr, M; Newton-Cheh, C; Nolte, IM; van der Harst, P; Muller, M; Eijgelsheim, M; Alonso, A (2010-12) -
Directional dominance on stature and cognition in diverse human populations
Joshi, PK; Esko, T; Mattsson, H; Eklund, N; Gandin, I; Nutile, T; Jackson, AU; Schurmann, C; Smith, AV; Zhang, W (2015-07-23) -
Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry
Graff, M; Justice, AE; Young, KL; Marouli, E; Zhang, X; Fine, RS; Lim, E; Buchanan, V; Rand, K; Feitosa, MF (2021) -
Discovery of novel heart rate-associated loci using the Exome Chip
van den Berg, ME; Warren, HR; Cabrera, CP; Verweij, N; Mifsud, B; Haessler, J; Bihlmeyer, NA; Fu, Y-P; Weiss, S; Lin, HJ (2017-06-15) -
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
Surendran, P; Feofanova, EV; Lahrouchi, N; Ntalla, I; Karthikeyan, S; Cook, J; Chen, L; Mifsud, B; Yao, C; Kraja, AT (2020) -
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals (vol 52, pg 1314, 2020)
Surendran, P; Feofanova, EV; Lahrouchi, N; Ntalla, I; Karthikeyan, S; Cook, J; Chen, L; Mifsud, B; Yao, C; Kraja, AT (2021) -
DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases
Wielscher, M; Mandaviya, PR; Kuehnel, B; Joehanes, R; Mustafa, R; Robinson, O; Zhang, Y; Bodinier, B; Walton, E; Mishra, PP (2022) -
Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups.
Kurniansyah, N; Goodman, MO; Khan, AT; Wang, J; Feofanova, E; Bis, JC; Wiggins, KL; Huffman, JE; Kelly, T; Elfassy, T (Springer Nature, 2023-06-02)We assess performance and limitations of polygenic risk scores (PRSs) for multiple blood pressure (BP) phenotypes in diverse population groups. We compare "clumping-and-thresholding" (PRSice2) and LD-based (LDPred2) methods ... -
Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6
Prins, BP; Mead, TJ; Brody, JA; Sveinbjornsson, G; Ntalla, I; Bihlmeyer, NA; van den Berg, M; Bork-Jensen, J; Cappellani, S; Van Duijvenboden, S (2018-07-17) -
Exome-wide association study of plasma lipids in > 300,000 individuals
Liu, DJ; Peloso, GM; Yu, H; Butterworth, AS; Wang, X; Mahajan, A; Saleheen, D; Emdin, C; Alam, D; Alves, AC (2017-12) -
ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals
Bihlmeyer, NA; Brody, JA; Smith, AV; Warren, HR; Lin, H; Isaacs, A; Liu, C-T; Marten, J; Radmanesh, F; Hall, LM (2018-01) -
Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.
de Las Fuentes, L; Sung, YJ; Noordam, R; Winkler, T; Feitosa, MF; Schwander, K; Bentley, AR; Brown, MR; Guo, X; Manning, A (Springer Nature, 2020-05-05)Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses ... -
Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci
de las Fuentes, L; Schwander, KL; Brown, MR; Bentley, AR; Winkler, TW; Sung, YJ; Munroe, PB; Miller, CL; Aschard, H; Aslibekyan, S -
Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
Young, WJ; Lahrouchi, N; Isaacs, A; Duong, TV; Foco, L; Ahmed, F; Brody, JA; Salman, R; Noordam, R; Benjamins, J-W (2022) -
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
Evangelou, E; Warren, HR; Mosen-Ansorena, D; Mifsu, B; Pazoki, R; Gao, H; Ntritsos, G; Dimou, N; Cabrer, CP; Karaman, I (2018-10) -
Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease.
Young, WJ; Haessler, J; Benjamins, J-W; Repetto, L; Yao, J; Isaacs, A; Harper, AR; Ramirez, J; Garnier, S; van Duijvenboden, S (2023-03-14)The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry ...