Browsing Centre for Clinical Pharmacology by Author "Pagano, PJ"
Now showing items 1-2 of 2
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Nox1/Ref-1-mediated activation of CREB promotes Gremlin1-driven endothelial cell proliferation and migration.
de Jesus, DS; DeVallance, E; Li, Y; Falabella, M; Guimaraes, D; Shiva, S; Kaufman, BA; Gladwin, MT; Pagano, PJ (2019-04)Pulmonary arterial hypertension (PAH) is a complex degenerative disorder marked by aberrant vascular remodeling associated with hyperproliferation and migration of endothelial cells (ECs). Previous reports implicated bone ... -
Specificity Protein 1-Mediated Promotion of CXCL12 Advances Endothelial Cell Metabolism and Proliferation in Pulmonary Hypertension.
DeVallance, ER; Dustin, CM; de Jesus, DS; Ghouleh, IA; Sembrat, JC; Cifuentes-Pagano, E; Pagano, PJ (2022-12-29)Pulmonary arterial hypertension (PAH) is a rare yet devastating and incurable disease with few treatment options. The underlying mechanisms of PAH appear to involve substantial cellular proliferation and vascular remodeling, ...