Browsing Centre for Clinical Pharmacology by Author "Padmanabhan, S"
Now showing items 1-20 of 47
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52 Genetic Loci Influencing Myocardial Mass
van der Harst, P; van Setten, J; Verweij, N; Vogler, G; Franke, L; Maurano, MT; Wang, X; Leach, IM; Eijgelsheim, M; Sotoodehnia, N (2016-09-27) -
Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double-Blind Randomized Controlled Trial.
MacDonald, TM; Williams, B; Webb, DJ; Morant, S; Caulfield, M; Cruickshank, JK; Ford, I; Sever, P; Mackenzie, IS; Padmanabhan, S (2017-11-18)BACKGROUND: Guidelines for hypertension vary in their preference for initial combination therapy or initial monotherapy, stratified by patient profile; therefore, we compared the efficacy and tolerability of these approaches. ... -
Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval
Lin, H; van Setten, J; Smith, AV; Bihlmeyer, NA; Warren, HR; Brody, JA; Radmanesh, F; Hall, L; Grarup, N; Mueller-Nurasyid, M (2018-05) -
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction
Sotoodehnia, N; Isaacs, A; de Bakker, PIW; Dorr, M; Newton-Cheh, C; Nolte, IM; van der Harst, P; Muller, M; Eijgelsheim, M; Alonso, A (2010-12) -
Corrigendum: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.
Warren, HR; Evangelou, E; Cabrera, CP; Gao, H; Ren, M; Mifsud, B; Ntalla, I; Surendran, P; Liu, C; Cook, JP (2017-09-27) -
Directional dominance on stature and cognition in diverse human populations
Joshi, PK; Esko, T; Mattsson, H; Eklund, N; Gandin, I; Nutile, T; Jackson, AU; Schurmann, C; Smith, AV; Zhang, W (2015-07-23) -
Discovery of novel heart rate-associated loci using the Exome Chip
van den Berg, ME; Warren, HR; Cabrera, CP; Verweij, N; Mifsud, B; Haessler, J; Bihlmeyer, NA; Fu, Y-P; Weiss, S; Lin, HJ (2017-06-15) -
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
Surendran, P; Feofanova, EV; Lahrouchi, N; Ntalla, I; Karthikeyan, S; Cook, J; Chen, L; Mifsud, B; Yao, C; Kraja, AT (2020) -
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals (vol 52, pg 1314, 2020)
Surendran, P; Feofanova, EV; Lahrouchi, N; Ntalla, I; Karthikeyan, S; Cook, J; Chen, L; Mifsud, B; Yao, C; Kraja, AT (2021) -
Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial
Brown, MJ; Williams, B; Morant, SV; Webb, DJ; Caulfield, MJ; Cruickshank, JK; Ford, I; McInnes, G; Sever, P; Salsbury, J (2016-02) -
Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals
Noordam, R; Young, WJ; Salman, R; Kanters, JK; van den Berg, ME; van Heemst, D; Lin, HJ; Barreto, SM; Biggs, ML; Biino, G (2019-06-25) -
Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies
Williams, B; MacDonald, TM; Morant, SV; Webb, DJ; Sever, P; McInnes, GT; Ford, I; Cruickshank, JK; Caulfield, MJ; Padmanabhan, S (2018-06) -
Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies.
Williams, B; MacDonald, TM; Morant, SV; Webb, DJ; Sever, P; McInnes, GT; Ford, I; Cruickshank, JK; Caulfield, MJ; Padmanabhan, S (2018-06)BACKGROUND: In the PATHWAY-2 study of resistant hypertension, spironolactone reduced blood pressure substantially more than conventional antihypertensive drugs. We did three substudies to assess the mechanisms underlying ... -
Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6
Prins, BP; Mead, TJ; Brody, JA; Sveinbjornsson, G; Ntalla, I; Bihlmeyer, NA; van den Berg, M; Bork-Jensen, J; Cappellani, S; Van Duijvenboden, S (2018-07-17) -
Exome-wide association study of plasma lipids in > 300,000 individuals
Liu, DJ; Peloso, GM; Yu, H; Butterworth, AS; Wang, X; Mahajan, A; Saleheen, D; Emdin, C; Alam, D; Alves, AC (2017-12) -
ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals
Bihlmeyer, NA; Brody, JA; Smith, AV; Warren, HR; Lin, H; Isaacs, A; Liu, C-T; Marten, J; Radmanesh, F; Hall, LM (2018-01) -
Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals Genomic Precision Medicine May Dispense With Ethnicity
Iniesta, R; Campbell, D; Venturini, C; Faconti, L; Singh, S; Irvin, MR; Cooper-DeHoff, RM; Johnson, JA; Turner, ST; Arnett, DK (2019-09) -
Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci
Tragante, V; Barnes, MR; Ganesh, SK; Lanktree, MB; Guo, W; Franceschini, N; Smith, EN; Johnson, T; Holmes, MV; Padmanabhan, S (2014-03-06) -
Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.
de Las Fuentes, L; Sung, YJ; Noordam, R; Winkler, T; Feitosa, MF; Schwander, K; Bentley, AR; Brown, MR; Guo, X; Manning, A (Springer Nature, 2020-05-05)Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses ... -
Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci
de las Fuentes, L; Schwander, KL; Brown, MR; Bentley, AR; Winkler, TW; Sung, YJ; Munroe, PB; Miller, CL; Aschard, H; Aslibekyan, S