Browsing Centre for Clinical Pharmacology by Author "O'Connell, JR"
Now showing items 1-20 of 22
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Defining the role of common variation in the genomic and biological architecture of adult human height
Wood, AR; Esko, T; Yang, J; Vedantam, S; Pers, TH; Gustafsson, S; Chun, AY; Estrada, K; Luan, J; Kutalik, Z (2014-11) -
Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci
Tragante, V; Barnes, MR; Ganesh, SK; Lanktree, MB; Guo, W; Franceschini, N; Smith, EN; Johnson, T; Holmes, MV; Padmanabhan, S (2014-03-06) -
Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
Young, WJ; Lahrouchi, N; Isaacs, A; Duong, TV; Foco, L; Ahmed, F; Brody, JA; Salman, R; Noordam, R; Benjamins, J-W (2022) -
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization
Arking, DE; Pulit, SL; Crotti, L; Van der Harst, P; Munroe, PB; Koopmann, TT; Sotoodehnia, N; Rossin, EJ; Morley, M; Wang, X (2014-08) -
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Pattaro, C; Teumer, A; Gorski, M; Chu, AY; Li, M; Mijatovic, V; Garnaas, M; Tin, A; Sorice, R; Li, Y (2016-01) -
Genetic studies of body mass index yield new insights for obesity biology
Locke, AE; Kahali, B; Berndt, SI; Justice, AE; Pers, TH; Day, FR; Powell, C; Vedantam, S; Buchkovich, ML; Yang, J (2015-02-12) -
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
Ehret, GB; Munroe, PB; Rice, KM; Bochud, M; Johnson, AD; Chasman, DI; Smith, AV; Tobin, MD; Verwoert, GC; Hwang, SJ (2011-10-06) -
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (vol 11, e1005378, 2015)
Winkler, TW; Justice, AE; Graff, M; Barata, L; Feitosa, MF; Chu, S; Czajkowski, J; Esko, T; Fall, T; Kilpelainen, TO (2016-06) -
Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension
Kelly, TN; Sun, X; He, KY; Brown, MR; Taliun, SAG; Hellwege, JN; Irvin, MR; Mi, X; Brody, JA; Franceschini, N (2022) -
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure
Sung, YJ; Winkler, TW; de las Fuentes, L; Bentley, AR; Brown, MR; Kraja, AT; Schwander, K; Ntalla, I; Guo, X; Franceschini, N (2018-03-01) -
Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.
de Vries, PS; Brown, MR; Bentley, AR; Sung, YJ; Winkler, TW; Ntalla, I; Schwander, K; Kraja, AT; Guo, X; Franceschini, N (Oxford University Press, 2019-01-29)An individual's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions ... -
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
Bentley, AR; Sung, YJ; Brown, MR; Winkler, TW; Kraja, AT; Ntalla, I; Schwander, K; Chasman, DI; Lim, E; Deng, X (Nature Research (part of Springer Nature), 2019-03-29)The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a ... -
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure
Sung, YJ; de Las Fuentes, L; Winkler, TW; Chasman, DI; Bentley, AR; Kraja, AT; Ntalla, I; Warren, HR; Guo, X; Schwander, K (2019-08-01) -
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
Ntalla, I; Weng, L-C; Cartwright, JH; Hall, AW; Sveinbjornsson, G; Tucker, NR; Choi, SH; Chaffin, MD; Roselli, C; Barnes, MR (2020-05-21) -
New genetic loci link adipose and insulin biology to body fat distribution
Shungin, D; Winkler, TW; Croteau-Chonka, DC; Ferreira, T; Lockes, AE; Maegi, R; Strawbridge, RJ; Pers, TH; Fischer, K; Justice, AE (2015-02-12) -
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries
Feitosa, MF; Kraja, AT; Chasman, DI; Sung, YJ; Winkler, TW; Ntalla, I; Guo, X; Franceschini, N; Cheng, C-Y; Sim, X (2018-06-18) -
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
Ried, JS; Jeff, JM; Chu, AY; Bragg-Gresham, JL; van Dongen, J; Huffman, JE; Ahluwalia, TS; Cadby, G; Eklund, N; Eriksson, J (2016-11-23) -
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.
Justice, AE; Karaderi, T; Highland, HM; Young, KL; Graff, M; Lu, Y; Turcot, V; Auer, PL; Fine, RS; Guo, X (Nature Research (part of Springer Nature), 2019-02-18)Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted ... -
Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
Lagou, V; Mägi, R; Hottenga, J-J; Grallert, H; Perry, JRB; Bouatia-Naji, N; Marullo, L; Rybin, D; Jansen, R; Min, JL (2021-02-08)Correction to: Nature Communications https://doi.org/10.1038/s41467-020-19366-9, published online 5 January 2021. The original version of this Article contained an error in Fig. 2, in which panels a and b were inadvertently ... -
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
Lagou, V; Mägi, R; Hottenga, J-J; Grallert, H; Perry, JRB; Bouatia-Naji, N; Marullo, L; Rybin, D; Jansen, R; Min, JL (Nature Research, 2021-01-05)Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in ...