Browsing Centre for Clinical Pharmacology by Author "O'Connell, J"
Now showing items 1-4 of 4
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Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.
de Las Fuentes, L; Sung, YJ; Noordam, R; Winkler, T; Feitosa, MF; Schwander, K; Bentley, AR; Brown, MR; Guo, X; Manning, A (Springer Nature, 2020-05-05)Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses ... -
Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.
Wang, H; Noordam, R; Cade, BE; Schwander, K; Winkler, TW; Lee, J; Sung, YJ; Bentley, AR; Manning, AK; Aschard, H (2021-04-15)Long and short sleep duration are associated with elevated blood pressure (BP), possibly through effects on molecular pathways that influence neuroendocrine and vascular systems. To gain new insights into the genetic basis ... -
Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration
Noordam, R; Bos, MM; Wang, H; Winkler, TW; Bentley, AR; Kilpelainen, TO; de Vries, PS; Sung, YJ; Schwander, K; Cade, BE (Nature Research (part of Springer Nature), 2019-11-12)Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide ... -
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.
Kilpeläinen, TO; Bentley, AR; Noordam, R; Sung, YJ; Schwander, K; Winkler, TW; Jakupović, H; Chasman, DI; Manning, A; Ntalla, I (Nature Research (part of Springer Nature), 2019-01-22)Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we ...