Browsing Centre for Clinical Pharmacology by Author "O'Brien, E"
Now showing items 1-3 of 3
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Efficacy and Safety of Incremental Dosing of a New Single-Pill Formulation of Perindopril and Amlodipine in the Management of Hypertension.
Poulter, NR; Dolan, E; Gupta, AK; O'Brien, E; Whitehouse, A; Sever, PS (Springer International Publishing, 2019-03-28)BACKGROUND: Angiotensin-converting enzyme inhibitors and calcium channel blockers in combination are widely recommended in hypertension guidelines. The advantages of single-pill combinations (SPCs) are increasingly recognized, ... -
Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane A2 formation and with cardiovascular event free survival in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT).
McCarthy, NS; Vangjeli, C; Surendran, P; Treumann, A; Rooney, C; Ho, E; Sever, P; Thom, S; Hughes, AD; Munroe, PB (2018-02)BACKGROUND AND AIMS: Elevated urinary 11-dehydro thromboxane B2 (TxB2), a measure of thromboxane A2 formation in vivo, predicts future atherothrombotic events. To further understand this relationship, the genetic determinants ... -
Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins
Postmus, I; Trompet, S; Deshmukh, HA; Barnes, MR; Li, X; Warren, HR; Chasman, DI; Zhou, K; Arsenault, BJ; Donnelly, LA (2014-10)