Browsing Centre for Clinical Pharmacology by Author "Faghri, F"
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Mitochondria function associated genes contribute to Parkinson's Disease risk and later age at onset
Billingsley, KJ; Barbosa, IA; Bandres-Ciga, S; Quinn, JP; Bubb, VJ; Deshpande, C; Botia, JA; Reynolds, RH; Zhang, D; Simpson, MA (Springer Nature, 2019-05-22)Mitochondrial dysfunction has been implicated in the etiology of monogenic Parkinson’s disease (PD). Yet the role that mitochondrial processes play in the most common form of the disease; sporadic PD, is yet to be fully ... -
Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson's disease heritability
Reynolds, RH; Botia, J; Nalls, MA; Hardy, J; Taliun, SAG; Ryten, M; Noyce, AJ; Nicolas, A; Cookson, MR; Bandres-Ciga, S (Springer Nature, 2019-04-17)Parkinson’s disease (PD), with its characteristic loss of nigrostriatal dopaminergic neurons and deposition of α-synuclein in neurons, is often considered a neuronal disorder. However, in recent years substantial evidence ... -
NeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases.
Blauwendraat, C; Faghri, F; Pihlstrom, L; Geiger, JT; Elbaz, A; Lesage, S; Corvol, J-C; May, P; Nicolas, A; Abramzon, Y (2017-09)Genetics has proven to be a powerful approach in neurodegenerative diseases research, resulting in the identification of numerous causal and risk variants. Previously, we introduced the NeuroX Illumina genotyping array, a ...