Browsing Centre for Clinical Pharmacology by Author "Evangelou, E"
Now showing items 1-20 of 32
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Corrigendum: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.
Warren, HR; Evangelou, E; Cabrera, CP; Gao, H; Ren, M; Mifsud, B; Ntalla, I; Surendran, P; Liu, C; Cook, JP (2017-09-27) -
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
Surendran, P; Feofanova, EV; Lahrouchi, N; Ntalla, I; Karthikeyan, S; Cook, J; Chen, L; Mifsud, B; Yao, C; Kraja, AT (2020) -
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals (vol 52, pg 1314, 2020)
Surendran, P; Feofanova, EV; Lahrouchi, N; Ntalla, I; Karthikeyan, S; Cook, J; Chen, L; Mifsud, B; Yao, C; Kraja, AT (2021) -
Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use
Brazel, DM; Jiang, Y; Hughey, JM; Turcot, V; Zhan, X; Gong, J; Batini, C; Weissenkampen, JD; Liu, M; Barnes, DR (2019-06-01) -
Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.
de Las Fuentes, L; Sung, YJ; Noordam, R; Winkler, T; Feitosa, MF; Schwander, K; Bentley, AR; Brown, MR; Guo, X; Manning, A (Springer Nature, 2020-05-05)Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses ... -
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
Evangelou, E; Warren, HR; Mosen-Ansorena, D; Mifsu, B; Pazoki, R; Gao, H; Ntritsos, G; Dimou, N; Cabrer, CP; Karaman, I (2018-10) -
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk (vol 49, pg 403, 2017)
Warren, HR; Evangelou, E; Cabrera, CP; Gao, H; Ren, M; Mifsud, B; Ntalla, I; Surendran, P; Liu, C; Cook, JP (2017-10) -
Genome-Wide Association Study of Blood Pressure Traits by Hispanic/Latino Background: the Hispanic Community Health Study/Study of Latinos
Sofer, T; Wong, Q; Hartwig, FP; Taylor, K; Warren, HR; Evangelou, E; Cabrera, CP; Levy, D; Kramer, H; Lange, LA (2017-09-04) -
Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study
Prins, BP; Abbasi, A; Wong, A; Vaez, A; Nolte, I; Franceschini, N; Stuart, PE; Achury, JG; Mistry, V; Bradfield, JP (2016-06) -
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure
Sung, YJ; Winkler, TW; de las Fuentes, L; Bentley, AR; Brown, MR; Kraja, AT; Schwander, K; Ntalla, I; Guo, X; Franceschini, N (2018-03-01) -
Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease
Marouli, E; Del Greco, MF; Astley, CM; Yang, J; Ahmad, S; Berndt, SI; Caulfield, MJ; Evangelou, E; McKnight, B; Medina-Gomez, C (2019-03-27) -
Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease.
Marouli, E; Del Greco, MF; Astley, CM; Yang, J; Ahmad, S; Berndt, SI; Caulfield, MJ; Evangelou, E; McKnight, B; Medina-Gomez, C (2019-03-27)There is evidence that lower height is associated with a higher risk of coronary artery disease (CAD) and increased risk of type 2 diabetes (T2D). It is not clear though whether these associations are causal, direct or ... -
Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.
Erzurumluoglu, AM; Liu, M; Jackson, VE; Barnes, DR; Datta, G; Melbourne, CA; Young, R; Batini, C; Surendran, P; Jiang, T (Springer Nature, 2019-01-07)Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with smoking ... -
Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.
de Vries, PS; Brown, MR; Bentley, AR; Sung, YJ; Winkler, TW; Ntalla, I; Schwander, K; Kraja, AT; Guo, X; Franceschini, N (Oxford University Press, 2019-01-29)An individual's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions ... -
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
Bentley, AR; Sung, YJ; Brown, MR; Winkler, TW; Kraja, AT; Ntalla, I; Schwander, K; Chasman, DI; Lim, E; Deng, X (Nature Research (part of Springer Nature), 2019-03-29)The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a ... -
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure
Sung, YJ; de Las Fuentes, L; Winkler, TW; Chasman, DI; Bentley, AR; Kraja, AT; Ntalla, I; Warren, HR; Guo, X; Schwander, K (2019-08-01) -
Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration
Noordam, R; Bos, MM; Wang, H; Winkler, TW; Bentley, AR; Kilpelainen, TO; de Vries, PS; Sung, YJ; Schwander, K; Cade, BE (Nature Research (part of Springer Nature), 2019-11-12)Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide ... -
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.
Kilpeläinen, TO; Bentley, AR; Noordam, R; Sung, YJ; Schwander, K; Winkler, TW; Jakupović, H; Chasman, DI; Manning, A; Ntalla, I (Nature Research (part of Springer Nature), 2019-01-22)Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we ... -
Multi-trait genome-wide association analysis of blood pressure identifies 45 additional loci
Cabrera, CP; Pazoki, R; Giri, A; Hellwege, JN; Evangelou, E; Ramirez, J; Wain, LV; Tzoulaki, I; Edwards, TL; Elliott, P (2020-12) -
New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475000 Individuals
Kraja, AT; Cook, JP; Warren, HR; Surendran, P; Liu, C; Evangelou, E; Manning, AK; Grarup, N; Drenos, F; Sim, X (American Heart Association, 2017-10-13)Background— Genome-wide association studies have recently identified >400 loci that harbor DNA sequence variants that influence blood pressure (BP). Our earlier studies identified and validated 56 single nucleotide variants ...