Browsing Centre for Clinical Pharmacology by Author "Cade, BE"
Now showing items 1-8 of 8
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Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry
Graff, M; Justice, AE; Young, KL; Marouli, E; Zhang, X; Fine, RS; Lim, E; Buchanan, V; Rand, K; Feitosa, MF (2021) -
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Kanoni, S; Graham, SE; Wang, Y; Surakka, I; Ramdas, S; Zhu, X; Clarke, SL; Bhatti, KF; Vedantam, S; Winkler, TW (2022) -
Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.
Wang, H; Noordam, R; Cade, BE; Schwander, K; Winkler, TW; Lee, J; Sung, YJ; Bentley, AR; Manning, AK; Aschard, H (2021-04-15)Long and short sleep duration are associated with elevated blood pressure (BP), possibly through effects on molecular pathways that influence neuroendocrine and vascular systems. To gain new insights into the genetic basis ... -
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
Bentley, AR; Sung, YJ; Brown, MR; Winkler, TW; Kraja, AT; Ntalla, I; Schwander, K; Chasman, DI; Lim, E; Deng, X (Nature Research (part of Springer Nature), 2019-03-29)The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a ... -
Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration
Noordam, R; Bos, MM; Wang, H; Winkler, TW; Bentley, AR; Kilpelainen, TO; de Vries, PS; Sung, YJ; Schwander, K; Cade, BE (Nature Research (part of Springer Nature), 2019-11-12)Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide ... -
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
Ramdas, S; Judd, J; Graham, SE; Kanoni, S; Wang, Y; Surakka, I; Wenz, B; Clarke, SL; Chesi, A; Wells, A (2022) -
A saturated map of common genetic variants associated with human height
Yengo, L; Vedantam, S; Marouli, E; Sidorenko, J; Bartell, E; Sakaue, S; Graff, M; Eliasen, AU; Jiang, Y; Raghavan, S (2022) -
The trans-ancestral genomic architecture of glycemic traits.
Chen, J; Spracklen, CN; Marenne, G; Varshney, A; Corbin, LJ; Luan, J; Willems, SM; Wu, Y; Zhang, X; Horikoshi, M (2021-05-31)Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide ...