Browsing Centre for Clinical Pharmacology by Author "Abis, G"
Now showing items 1-4 of 4
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15-deoxy-Delta(12,14)-Prostaglandin J(2) inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism
Abis, G; Charles, RL; Kopec, J; Yue, WW; Atkinson, RA; Bui, TTT; Lynham, S; Popova, S; Sun, Y-B; Fraternali, F (Nature Research, 2019-05-17) -
Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation.
Knight, H; Abis, G; Kaur, M; Green, HLH; Krasemann, S; Hartmann, K; Lynham, S; Clark, J; Zhao, L; Ruppert, C (2023-11-13)BACKGROUND: Pulmonary hypertension (PH) is a chronic vascular disease characterized, among other abnormalities, by hyperproliferative smooth muscle cells and a perturbed cellular redox and metabolic balance. Oxidants induce ... -
PDXK mutations cause polyneuropathy responsive to pyridoxal 5'-phosphate supplementation.
Chelban, V; Wilson, MP; Warman Chardon, J; Vandrovcova, J; Zanetti, MN; Zamba-Papanicolaou, E; Efthymiou, S; Pope, S; Conte, MR; Abis, G (2019-08)OBJECTIVE: To identify disease-causing variants in autosomal recessive axonal polyneuropathy with optic atrophy and provide targeted replacement therapy. METHODS: We performed genome-wide sequencing, homozygosity mapping, ... -
A thiol redox sensor in soluble epoxide hydrolase enables oxidative activation by intra-protein disulfide bond formation
Charles, RL; Abis, G; Fernandez, BF; Guttzeit, S; Buccafusca, R; Conte, MR; Eaton, P (Elsevier, 2021-08-18)