Browsing Centre for Psychiatry by Subject "schizophrenia"
Now showing items 1-20 of 27
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Cannabis use and psychotic disorders in diverse settings in the Global South: findings from INTREPID II.
(2023-11)BACKGROUND: Cannabis use has been linked to psychotic disorders but this association has been primarily observed in the Global North. This study investigates patterns of cannabis use and associations with psychoses in three ... -
Construction of an Exome-Wide Risk Score for Schizophrenia Based on a Weighted Burden Test.
(2018-01)Polygenic risk scores obtained as a weighted sum of associated variants can be used to explore association in additional data sets and to assign risk scores to individuals. The methods used to derive polygenic risk scores ... -
Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood.
(2018-06-07)Genetic correlation is a key population parameter that describes the shared genetic architecture of complex traits and diseases. It can be estimated by current state-of-art methods, i.e., linkage disequilibrium score ... -
Eyes, the window on psychosis?
(2022) -
Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes.
(2018-06-14)Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology. Understanding the genetic factors contributing to the shared and disorder-specific symptoms will be crucial for improving diagnosis and ... -
Mini-review: Update on the genetics of schizophrenia.
(2018-09)A number of important findings have recently emerged relevant to identifying genetic risk factors for schizophrenia. Findings using common variants point towards gene sets of interest and also demonstrate an overlap with ... -
Mutation intolerant genes and targets of FMRP are enriched for nonsynonymous alleles in schizophrenia.
(2017-10)Risk of schizophrenia is conferred by alleles occurring across the full spectrum of frequencies from common SNPs of weak effect through to ultra rare alleles, some of which may be moderately to highly penetrant. Previous ...