Browsing Centre for Psychiatry by Subject "Schizophrenia"
Now showing items 1-20 of 33
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Age at first birth in women is genetically associated with increased risk of schizophrenia.
(2018-07-05)Previous studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent ... -
Association study of schizophrenia with variants in miR-137 binding sites.
(2018-07)There is strong cumulative evidence for the involvement of miR-137 and its targets in the aetiology of schizophrenia. Here we test whether variants, especially rare variants, in miR-137 binding sites are associated with ... -
Clinicians have several therapeutic relationships and patients only one: The effect on their assessments of relationships.
(2018-12)OBJECTIVES: Little attention has been given to the common assessment problem that clinicians assess outcomes of several patients and may rate them in comparison to one another, whereas patients assess only their own outcomes ... -
Construction of an Exome-Wide Risk Score for Schizophrenia Based on a Weighted Burden Test.
(2018-01)Polygenic risk scores obtained as a weighted sum of associated variants can be used to explore association in additional data sets and to assign risk scores to individuals. The methods used to derive polygenic risk scores ... -
Correspondence between negative symptoms and potential sources of secondary negative symptoms over time.
(2018-09)There has been a debate in the literature about the distinction between primary and secondary negative symptoms of schizophrenia. Our aim was to study the associations between negative symptoms and potential sources of ... -
Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood.
(2018-06-07)Genetic correlation is a key population parameter that describes the shared genetic architecture of complex traits and diseases. It can be estimated by current state-of-art methods, i.e., linkage disequilibrium score ... -
Ethnic inequalities in the incidence of diagnosis of severe mental illness in England: a systematic review and new meta-analyses for non-affective and affective psychoses.
(2019-11)PURPOSE: Although excess risks particularly for a diagnosis of schizophrenia have been identified for ethnic minority people in England and other contexts, we sought to identify and synthesise up-to-date evidence (2018) ... -
Gender differences in coerced patients with schizophrenia
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Genetic correlation between amyotrophic lateral sclerosis and schizophrenia.
(2017-03-21)We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the ... -
Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.
(2009-06)Translating a set of disease regions into insight about pathogenic mechanisms requires not only the ability to identify the key disease genes within them, but also the biological relationships among those key genes. Here ...