Browsing Centre for Psychiatry by Subject "Genotype"
Now showing items 1-3 of 3
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A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework.
(2018-06-25)BACKGROUND: There is considerable evidence that many complex traits have a partially shared genetic basis, termed pleiotropy. It is therefore useful to consider integrating genome-wide association study (GWAS) data across ... -
Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood.
(2018-06-07)Genetic correlation is a key population parameter that describes the shared genetic architecture of complex traits and diseases. It can be estimated by current state-of-art methods, i.e., linkage disequilibrium score ... -
Polygenic risk score for schizophrenia is more strongly associated with ancestry than with schizophrenia.
(2018-10)BACKGROUND: The polygenic risk score (PRS) for schizophrenia, derived from very large numbers of weakly associated genetic markers, has been repeatedly shown to be robustly associated with schizophrenia in independent ...