Browsing Centre for Psychiatry by Subject "Genome-Wide Association Study"
Now showing items 1-7 of 7
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A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework.
(2018-06-25)BACKGROUND: There is considerable evidence that many complex traits have a partially shared genetic basis, termed pleiotropy. It is therefore useful to consider integrating genome-wide association study (GWAS) data across ... -
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia.
(2017-03-21)We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the ... -
Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.
(2009-06)Translating a set of disease regions into insight about pathogenic mechanisms requires not only the ability to identify the key disease genes within them, but also the biological relationships among those key genes. Here ... -
Mutation intolerant genes and targets of FMRP are enriched for nonsynonymous alleles in schizophrenia.
(2017-10)Risk of schizophrenia is conferred by alleles occurring across the full spectrum of frequencies from common SNPs of weak effect through to ultra rare alleles, some of which may be moderately to highly penetrant. Previous ... -
No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study.
(2016-10)It is well known that inbreeding increases the risk of recessive monogenic diseases, but it is less certain whether it contributes to the etiology of complex diseases such as schizophrenia. One way to estimate the effects ... -
Polygenic risk score for schizophrenia is more strongly associated with ancestry than with schizophrenia.
(2018-10)BACKGROUND: The polygenic risk score (PRS) for schizophrenia, derived from very large numbers of weakly associated genetic markers, has been repeatedly shown to be robustly associated with schizophrenia in independent ... -
Polygenic risk score for schizophrenia is not strongly associated with the expression of specific genes or gene sets.
(2018-08)BACKGROUND: The polygenic risk score (PRS) is derived from single nucleotide polymorphisms (SNPs) including those that are genome-wide significant and also including a large number of others more weakly associated with ...