Wolfson Institute of Preventive Medicine: Recent submissions
Now showing items 1-20 of 1055
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Sodium Reduction, Metabolomic Profiling and CVD risk in Untreated Black Hypertensives: a Randomized, Double-Blind, Placebo-Controlled Trial
(American Heart Association, 2019-05-13)Dietary sodium restriction has multiple beneficial effects on cardiovascular health. The underlying mechanisms are not fully understood, and the roles of metabolomics have been rarely studied. We aimed to test the hypothesis ... -
Frontotemporal Dementia: A Clinical Review.
(Thieme Publishing, 2019-04)Frontotemporal dementias are a clinically, neuroanatomically, and pathologically diverse group of diseases that collectively constitute an important cause of young-onset dementia. Clinically, frontotemporal dementias ... -
Probability of cancer in lung nodules using sequential volumetric screening up to 12 months: the UKLS trial.
(BMJ, 2019-04-26)BACKGROUND: Estimation of the clinical probability of malignancy in patients with pulmonary nodules will facilitate early diagnosis, determine optimum patient management strategies and reduce overall costs. METHODS: Data ... -
Segmentation of medial temporal subregions reveals early right-sided involvement in semantic variant PPA
(BioMed Central, 2019-05-10)Background: Semantic variant of primary progressive aphasia (svPPA) is a subtype of frontotemporal dementia characterized by asymmetric temporal atrophy. Methods: We investigated the pattern of medial temporal lobe ... -
Screening performance of abbreviated versions of the UPSIT smell test.
(Springer Berlin Heidelberg, 2019-05-03)BACKGROUND: Hyposmia can develop with age and in neurodegenerative conditions, including Parkinson's disease (PD). The University of Pennsylvania Smell Identification Test (UPSIT) is a 40-item smell test widely used for ... -
How to design psychiatric facilities to foster positive social interaction – A systematic review
(Elsevier BV, 2019-05-18)Psychiatric facilities are often criticised of being poorly designed which may contribute to violent incidents and patients’ complaints of feeling bored and lacking meaningful interactions with peers and staff. There is a ... -
Genome-wide association study identifies 30 loci associated with bipolar disorder.
(Springer Nature, 2019-05-01)Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with ... -
Predictors of moving on from mental health supported accommodation in England: national cohort study.
(Cambridge University Press (CUP), 2019-05-03)BACKGROUND: Around 60 000 people in England live in mental health supported accommodation. There are three main types: residential care, supported housing and floating outreach. Supported housing and floating outreach aim ... -
Comparison of risedronate versus placebo in preventing anastrozole-induced bone loss in women at high risk of developing breast cancer with osteopenia.
(Elsevier, 2019-04-24)Anastrozole has been shown to prevent breast cancer in postmenopausal women at high risk of the disease, but has been associated with substantial accelerated loss of bone mineral density (BMD) and increased fractures. Here, ... -
Prediction of chemotherapy benefit by EndoPredict in patients with breast cancer who received adjuvant endocrine therapy plus chemotherapy or endocrine therapy alone
(Springer US, 2019-04-30)PURPOSE: EndoPredict (EPclin) is a prognostic test validated to inform decisions on adjuvant chemotherapy to endocrine therapy alone for patients with oestrogen receptor-positive, HER2-negative breast cancer. Here, we ... -
Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia.
(Wiley, 2019-02-23)Genome-wide association studies (GWASs) are highly effective at identifying common risk variants for schizophrenia. Rare risk variants are also important contributors to schizophrenia etiology but, with the exception of ... -
Liquid Biopsy for Cancer Diagnosis and Screening – The Promise and Challenges
(SAGE Publications, 2019-04-11)Liquid biopsy in cancer refers to isolation and analysis of tumour-derived materials such as DNA, RNA, intact cancer cells and extracellular vesicles in bodily fluids such as blood, urine, saliva, and stools. It has the ... -
The return of the traumatized army veteran: a qualitative study of UK ex-servicemen in the aftermath of war, 1945 to 2000
(Informa Healthcare, 2019-04-18)The challenge of transition from service to civilian life is explored through the experiences of a sample of 225 UK army veterans between 1945 and 2000. All subjects had a war pension for a psychological disorder, and most ... -
The International Consortium for Quality Research on Dietary Sodium/Salt (TRUE) position statement on the use of 24-hour, spot and short duration (less than 24-hours) timed urine collections to assess dietary sodium intake.
(Wiley, 2019-05-14)The International Consortium for Quality Research on Dietary Sodium/Salt (TRUE) is a coalition of intentional and national health and scientific organizations formed because of concerns low‐quality research methods were ... -
The impact of a brief gratitude intervention on subjective well-being, biology and sleep
(Sage, 2015-03-02)This randomised controlled experiment tested whether a brief subjective well-being (SWB) intervention would have favourable effects on cardiovascular and neuroendocrine function and on sleep. We compared 2 weeks of a ... -
Web-Based Measure of Life Events Using Computerized Life Events and Assessment Record (CLEAR): Preliminary Cross-Sectional Study of Reliability, Validity, and Association With Depression.
(JMIR Publications, 2019-01-08)BACKGROUND: Given the criticisms of life event checklists and the costs associated with interviews, life event research requires a sophisticated but easy-to-use measure for research and clinical practice. Therefore, the ... -
Characteristics of severe life events, attachment style, and depression – Using a new online approach
(Wiley, 2019-04-13)Objectives: Severe life events are established as provoking agents for depression in combination with vulnerability factors. Identifying features of severe events improves the prediction of disorder but are rarely utilized, ... -
The Parkinson’s Phenome—Traits Associated with Parkinson's Disease in a Broadly Phenotyped Cohort
(2019-03-27)In order to systematically describe the Parkinson’s disease phenome, we performed a series of 832 cross-sectional case-control analyses in a large database. Responses to 832 online survey-based phenotypes including diseases, ... -
Biological and psychological correlates of self-reported and objective sleep measures
(Elsevier, 2016-03-23)OBJECTIVE: Objective and self-reported sleep are only moderately correlated and it is uncertain if these two types of sleep measures are associated with distinct biological and psychological outcomes. METHODS: Participants ...
