Wolfson Institute of Preventive Medicine: Recent submissions
Now showing items 1-20 of 1785
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Polygenic resilience modulates the penetrance of Parkinson's disease genetic risk factors.
(2022-05-22)OBJECTIVE: The aim of the current study is to understand why some individuals avoid developing Parkinson's disease (PD) in spite of being at relatively high genetic risk, using the largest datasets of individual-level ... -
Authors' Response to Peer Reviews of “Using Structural Equation Modelling in Routine Clinical Data on Diabetes and Depression: Observational Cohort Study”
(2022-04-27)Background: Large data sets comprising routine clinical data are becoming increasingly available for use in health research. These data sets contain many clinical variables that might not lend themselves to use in research. ... -
Artificial intelligence and machine learning algorithms for early detection of skin cancer in community and primary care settings: a systematic review.
(2022-06)Skin cancers occur commonly worldwide. The prognosis and disease burden are highly dependent on the cancer type and disease stage at diagnosis. We systematically reviewed studies on artificial intelligence and machine ... -
Benefit of biennial faecal occult blood screening on colorectal cancer in England: A population-based case-control study.
(2022-05-16)BACKGROUND: The English national bowel cancer screening programme(NHSBCSP) offering a guaiac faecal occult blood test (gFOBT) began in July 2006. In randomised controlled trials of gFOBT screening, reductions in mortality ... -
EZH2 inhibitor tazemetostat in patients with relapsed or refractory, BAP1-inactivated malignant pleural mesothelioma: a multicentre, open-label, phase 2 study.
(2022-06)BACKGROUND: Treatment options for malignant pleural mesothelioma are scarce. Tazemetostat, a selective oral enhancer of zeste homolog 2 (EZH2) inhibitor, has shown antitumour activity in several haematological cancers and ... -
Seroconversion following COVID-19 vaccination: can we optimize protective response in CD20-treated individuals?
(2022-05-12)Although there is an ever-increasing number of disease-modifying treatments for relapsing multiple sclerosis (MS), few appear to influence coronavirus disease 2019 (COVID-19) severity. There is concern about the use of ... -
The influence of anemia on clinical outcomes in venous thromboembolism: Results from GARFIELD-VTE.
(2021-07)INTRODUCTION: Clinical characteristics and outcomes of venous thromboembolism (VTE) patients with concomitant anemia are unclear. This study compares baseline characteristics, treatment patterns, and 24-month outcomes in ...
