Browsing Wolfson Institute of Preventive Medicine by Subject "Risk"
Now showing items 1-7 of 7
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Association study of schizophrenia with variants in miR-137 binding sites.
(2018-07)There is strong cumulative evidence for the involvement of miR-137 and its targets in the aetiology of schizophrenia. Here we test whether variants, especially rare variants, in miR-137 binding sites are associated with ... -
Construction of an Exome-Wide Risk Score for Schizophrenia Based on a Weighted Burden Test.
(2018-01)Polygenic risk scores obtained as a weighted sum of associated variants can be used to explore association in additional data sets and to assign risk scores to individuals. The methods used to derive polygenic risk scores ... -
The dose-response relationship between cigarette consumption, biochemical markers and risk of lung cancer.
(1997)The relationship between the number of cigarettes smoked per day and the incidence of lung cancer is linear but, from the multistage model of carcinogenesis, it should be quadratic (upwards curving). We investigated this ... -
Future cancer risk after urgent suspected cancer referral in England when cancer is not found: a national cohort study.
(2023-11)BACKGROUND: Following referral for investigation of urgent suspected cancer within the English National Health Service referral system, 7% of referred individuals are diagnosed with cancer. This study aimed to investigate ... -
Parkinson's disease in GTP cyclohydrolase 1 mutation carriers.
(2014-09)GTP cyclohydrolase 1, encoded by the GCH1 gene, is an essential enzyme for dopamine production in nigrostriatal cells. Loss-of-function mutations in GCH1 result in severe reduction of dopamine synthesis in nigrostriatal ...