Browsing Wolfson Institute of Preventive Medicine by Author "O'Donovan, MC"
Now showing items 1-14 of 14
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Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
Marshall, CR; Marshall, CR; Howrigan, DP; Merico, D; Thiruvahindrapuram, B; Wu, W; Greer, DS; Antaki, D; Shetty, A; Holmans, PA (2017-01) -
The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability
Singh, T; Walters, JTR; Johnstone, M; Curtis, D; Suvisaari, J; Torniainen, M; Rees, E; Iyegbe, C; Blackwood, D; McIntosh, AM (2017-08) -
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
Mullins, N; Kang, J; Campos, AI; Coleman, JRI; Edwards, AC; Galfalvy, H; Levey, DF; Lori, A; Shabalin, A; Starnawska, A (2022-02-01) -
Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia
Palmer, DS; Howrigan, DP; Chapman, SB; Adolfsson, R; Bass, N; Blackwood, D; Boks, MPM; Chen, C-Y; Churchhouse, C; Corvin, AP (2022) -
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
Huckins, LM; Dobbyn, A; Ruderfer, DM; Hoffman, G; Wang, W; Pardinas, AF; Rajagopal, VM; Als, TD; Nguyen, HT; Girdhar, K (Springer Nature, 2019-03-25)Transcriptomic imputation approaches combine eQTL reference panels with large-scale genotype data in order to test associations between disease and gene expression. These genic associations could elucidate signals in complex ... -
Genome-wide association study identifies 30 loci associated with bipolar disorder
Stahl, EA; Breen, G; Forstner, AJ; McQuillin, A; Ripke, S; Trubetskoy, V; Mattheisen, M; Wang, Y; Coleman, JRI; Gaspar, HA (2019-05) -
Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia
Witt, SH; Streit, F; Jungkunz, M; Frank, J; Awasthi, S; Reinbold, CS; Treutlein, J; Degenhardt, F; Forstner, AJ; Heilmann-Heimbach, S (2017-06-20) -
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders
Lee, PH; Anttila, V; Won, H; Feng, Y-CA; Rosenthal, J; Zhu, Z; Tucker-Drob, EM; Nivard, MG; Grotzinger, AD; Posthuma, D (2019-12-12) -
Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia.
Pardiñas, AF; Smart, SE; Willcocks, IR; Holmans, PA; Dennison, CA; Lynham, AJ; Legge, SE; Baune, BT; Bigdeli, TB; Cairns, MJ (2022-03-01)Importance: About 20% to 30% of people with schizophrenia have psychotic symptoms that do not respond adequately to first-line antipsychotic treatment. This clinical presentation, chronic and highly disabling, is known as ... -
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Trubetskoy, V; Pardinas, AF; Qi, T; Panagiotaropoulou, G; Awasthi, S; Bigdeli, TB; Bryois, J; Chen, C-Y; Dennison, CA; Hall, LS (2022) -
Mutation intolerant genes and targets of FMRP are enriched for nonsynonymous alleles in schizophrenia.
Leonenko, G; Richards, AL; Walters, JT; Pocklington, A; Chambert, K; Al Eissa, MM; Sharp, SI; O'Brien, NL; Curtis, D; Bass, NJ (2017-10)Risk of schizophrenia is conferred by alleles occurring across the full spectrum of frequencies from common SNPs of weak effect through to ultra rare alleles, some of which may be moderately to highly penetrant. Previous ... -
Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia.
Harold, D; Connolly, S; Riley, BP; Kendler, KS; McCarthy, SE; McCombie, WR; Richards, A; Owen, MJ; O'Donovan, MC; Walters, J (2019-04)Genome-wide association studies (GWASs) are highly effective at identifying common risk variants for schizophrenia. Rare risk variants are also important contributors to schizophrenia etiology but, with the exception of ... -
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways
O'Dushlaine, C; Rossin, L; Lee, PH; Duncan, L; Parikshak, NN; Newhouse, S; Ripke, S; Neale, BM; Purcell, SM; Posthuma, D (2015-02) -
Rare coding variants in ten genes confer substantial risk for schizophrenia
Singh, T; Poterba, T; Curtis, D; Akil, H; Al Eissa, M; Barchas, JD; Bass, N; Bigdeli, TB; Breen, G; Bromet, EJ (2022)