Browsing Wolfson Institute of Preventive Medicine by Author "Iwaki, H"
Now showing items 1-10 of 10
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Differences in the presentation and progression of Parkinson's disease by sex
Iwaki, H; Blauwendraat, C; Leonard, HL; Makarious, MB; Kim, JJ; Liu, G; Maple-Grødem, J; Corvol, J-C; Pihlstrøm, L; van Nimwegen, M (2020-04-11) -
Differences in the Presentation and Progression of Parkinson's Disease by Sex
Iwaki, H; Blauwendraat, C; Leonard, HL; Makarious, MB; Kim, JJ; Liu, G; Maple-Grodem, J; Corvol, J-C; Pihlstrom, L; van Nimwegen, M (Wiley, 2020-10-01) -
Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia.
Blauwendraat, C; Reed, X; Krohn, L; Heilbron, K; Bandres-Ciga, S; Tan, M; Gibbs, JR; Hernandez, DG; Kumaran, R; Langston, R (2020-01-01)Parkinson's disease is a genetically complex disorder. Multiple genes have been shown to contribute to the risk of Parkinson's disease, and currently 90 independent risk variants have been identified by genome-wide association ... -
Genetic risk of Parkinson disease and progression: An analysis of 13 longitudinal cohorts
Iwaki, H; Blauwendraat, C; Leonard, HL; Liu, G; Maple-Grødem, J; Corvol, JC; Pihlstrøm, L; Van Nimwegen, M; Hutten, SJ; Nguyen, KDH (2019-08-01)Copyright © 2019 The Author(s). Objective To determine if any association between previously identified alleles that confer risk for Parkinson disease and variables measuring disease progression. Methods We evaluated the ... -
Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts.
Iwaki, H; Blauwendraat, C; Leonard, HL; Kim, JJ; Liu, G; Maple-Grødem, J; Corvol, J-C; Pihlstrøm, L; van Nimwegen, M; Hutten, SJ (2019-12)BACKGROUND: Several reports have identified different patterns of Parkinson's disease progression in individuals carrying missense variants in GBA or LRRK2 genes. The overall contribution of genetic factors to the severity ... -
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
Nalls, MA; Blauwendraat, C; Vallerga, CL; Heilbron, K; Bandres-Ciga, S; Chang, D; Tan, M; Kia, DA; Noyce, AJ; Xue, A (2019-12) -
Investigation of Autosomal Genetic Sex Differences in Parkinson's disease.
Blauwendraat, C; Iwaki, H; Makarious, MB; Bandres-Ciga, S; Leonard, H; Grenn, FP; Lake, J; Krohn, L; Tan, M; Kim, JJ (2021-04-26)OBJECTIVE: Parkinson's disease (PD) is a complex neurodegenerative disorder. Males are on average ~ 1.5 times more likely to develop PD compared to females with European ancestry. Over the years genome-wide association ... -
The IPDGC/GP2 Hackathon - an open science event for training in data science, genomics, and collaboration using Parkinson's disease data (vol 9, 33, 2023)
Leonard, HL; Murtadha, R; Martinez-Carrasco, A; Jama, A; Mueller-Nedebock, AC; Gil-Martinez, A-L; Illarionova, A; Moore, A; Bustos, BI; Jadhav, B (2023) -
Large-scale pathway specific polygenic risk and transcriptomic community network analysis identifies novel functional pathways in Parkinson disease
Bandres-Ciga, S; Saez-Atienzar, S; Kim, JJ; Makarious, MB; Faghri, F; Diez-Fairen, M; Iwaki, H; Leonard, H; Botia, J; Ryten, M (2020-09) -
Multi-ancestry genome-wide association meta-analysis of Parkinson's disease.
Kim, JJ; Vitale, D; Otani, DV; Lian, MM; Heilbron, K; 23andMe Research Team; Iwaki, H; Lake, J; Solsberg, CW; Leonard, H (2024-01)Although over 90 independent risk variants have been identified for Parkinson's disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale ...