Awaiting Allocation: Recent submissions
Now showing items 161-180 of 247
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Topoisomerase I poison-triggered immune gene activation is markedly reduced in human small-cell lung cancers by impairment of the cGAS/STING pathway.
(Cell Press, 2022-10-07)BACKGROUND: Current immunotherapy strategies have contrasting clinical results in human lung cancer patients as small-cell lung cancers (SCLC) often show features of immunological cold tumours. Topoisomerase 1 (TOP1) poisons ... -
USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development
(Cell Press, 2023-01-19)Adenomatous polyposis coli (APC) mutation is the hallmark of colorectal cancer (CRC), resulting in constitutive WNT activation. Despite decades of research, targeting WNT signaling in cancer remains challenging due to its ... -
Observational and genetic associations between cardiorespiratory fitness and cancer: a UK Biobank and international consortia study
(Springer Nature, 2023-12-06)BACKGROUND: The association of fitness with cancer risk is not clear. METHODS: We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for risk of lung, colorectal, ... -
How to use the HOME Core Outcome Set for atopic dermatitis trials - a users' guide.
(2023-12-20)The Harmonizing Outcome Measures for Eczema (HOME) initiative has agreed upon the core outcome set for use in atopic dermatitis (AD) clinical trials, but additional guidance is needed to maximise uptake of the core set. ... -
Tryptophan to Tryptophan Hole Hopping in an Azurin Construct.
(2024-01-11)Electron transfer (ET) between neutral and cationic tryptophan residues in the azurin construct [ReI(H126)(CO)3(dmp)](W124)(W122)CuI (dmp = 4,7-Me2-1,10-phenanthroline) was investigated by Born-Oppenheimer quantum-mechan ... -
Risk factors associated with poor pain outcomes following primary knee replacement surgery: Analysis of data from the clinical practice research datalink, hospital episode statistics and patient reported outcomes as part of the STAR research programme
<jats:sec id="sec001"> <jats:title>Objective</jats:title> <jats:p>Identify risk factors for poor pain outcomes six months after primary knee replacement surgery.</jats:p> </jats:sec> <jats:sec id="sec002"> <jats:title>Me ... -
Recommendations from the ICM-VTE: Trauma
(Ovid Technologies (Wolters Kluwer Health), 2022-03-16) -
How long does an elbow replacement last? A systematic review and meta-analysis of case-series and national registry reports with more than 10 years of follow-up
<jats:p>Background and purpose: This study aims to determine, for the first time, generalizable data on the longevity and long-term function of elbow replacements.Methods: In this systematic review and meta-analysis, we ... -
Age stratified, matched comparison of unicompartmental and total knee replacement.
(2020-10)BACKGROUND: Unicompartmental knee replacement (UKR) tends to provide better function but has a higher revision rate than total knee replacement (TKR). The aim was to determine if this occurred in all age groups. METHODS: ... -
The Mid- to Long-Term Outcomes of the Lateral Domed Oxford Unicompartmental Knee Replacement: An Analysis From the National Joint Registry for England, Wales, Northern Ireland, and the Isle of Man.
(2021-01)BACKGROUND: Lateral unicompartmental knee replacement (UKR) is an alternative to total knee replacement for isolated lateral unicompartmental knee arthritis. The geometry and mechanics of the lateral compartment differ to ... -
The effect of body mass index on the outcomes of cementless medial mobile-bearing unicompartmental knee replacements
(Springer Science and Business Media LLC, 2023-02)<jats:title>Abstract</jats:title><jats:sec> <jats:title>Purpose</jats:title> <jats:p>Given an increasingly overweight population, unicompartmental knee replacements (UKRs) are being performed in patients with higher body ... -
A Matched Comparison of the Long-Term Outcomes of Cemented and Cementless Total Knee Replacements
(Ovid Technologies (Wolters Kluwer Health), 2021-12-15)<jats:sec> <jats:title>Background:</jats:title> <jats:p>Total knee replacements (TKRs) can be implanted with or without the use of cement. It is currently uncertain how cemented and cementless TKRs compare overall and in ... -
A matched comparison of the patient-reported outcome measures of 38,716 total and unicompartmental knee replacements: an analysis of linked data from the National Joint Registry of England, Northern Ireland and Isle of Man and England’s National PROM collection programme
(Medical Journals Sweden AB, 2021-11-02)