Awaiting Allocation: Recent submissions
Now showing items 101-120 of 247
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B-cell-specific checkpoint molecules that regulate anti-tumour immunity.
(2023-07)The role of B cells in anti-tumour immunity is still debated and, accordingly, immunotherapies have focused on targeting T and natural killer cells to inhibit tumour growth1,2. Here, using high-throughput flow cytometry ... -
Increased fidelity of protein synthesis extends lifespan.
(Cell Press, 2021-09-14)Loss of proteostasis is a fundamental process driving aging. Proteostasis is affected by the accuracy of translation, yet the physiological consequence of having fewer protein synthesis errors during multi-cellular organismal ... -
Crosstalk between the mTOR and DNA Damage Response Pathways in Fission Yeast.
(MDPI, 2021-02-02)Cells have developed response systems to constantly monitor environmental changes and accordingly adjust growth, differentiation, and cellular stress programs. The evolutionarily conserved, nutrient-responsive, mechanistic ... -
Genome-wide screens in yeast models towards understanding chronological lifespan regulation.
(Oxford University Press, 2021-03-17)Cellular models such as yeasts are a driving force in biogerontology studies. Their simpler genome, short lifespans and vast genetic and genomics resources make them ideal to characterise pro-ageing and anti-ageing genes ... -
Nutrient-Response Pathways in Healthspan and Lifespan Regulation.
(MDPI, 2022-05-06)Cellular, small invertebrate and vertebrate models are a driving force in biogerontology studies. Using various models, such as yeasts, appropriate tissue culture cells, Drosophila, the nematode Caenorhabditis elegans and ... -
Interplays of AMPK and TOR in Autophagy Regulation in Yeast.
(MDPI, 2023-02-04)Cells survey their environment and need to balance growth and anabolism with stress programmes and catabolism towards maximum cellular bioenergetics economy and survival. Nutrient-responsive pathways, such as the mechanistic ... -
Amino Acids Whose Intracellular Levels Change Most During Aging Alter Chronological Life Span of Fission Yeast.
(Oxford University Press, 2020-11-03)Amino acid deprivation or supplementation can affect cellular and organismal life span, but we know little about the role of concentration changes in free, intracellular amino acids during aging. Here, we determine free ... -
The longevity and reversibility of quiescence in Schizosaccharomyces pombe are dependent upon the HIRA histone chaperone
(Taylor and Francis Group, 2023-08-27)Quiescence (G0) is a reversible non-dividing state that facilitates cellular survival in adverse conditions. Here, we demonstrate that the HIRA histone chaperone complex is required for the reversibility and longevity of ... -
New Calabi-Yau Manifolds from Genetic Algorithms
(2023-06-09) -
Machine-learning dessins d’enfants: Explorations via modular and Seiberg–Witten curves
(2021-02-19)We apply machine-learning to the study of dessins d’enfants. Specifically, we investigate a class of dessins which reside at the intersection of the investigations of modular subgroups, Seiberg–Witten (SW) curves and ... -
New Calabi–Yau manifolds from genetic algorithms
(2024-03-01)Calabi–Yau manifolds can be obtained as hypersurfaces in toric varieties built from reflexive polytopes. We generate reflexive polytopes in various dimensions using a genetic algorithm. As a proof of principle, we demonstrate ... -
Comparative Investigation of the Microstructure of MgCl2 Aqueous Solutions Using Different X-ray Scattering Sources, Raman Spectroscopy, and Atomistic Simulations.
(2024-01-11)Aqueous solutions of magnesium chloride (MgCl2(aq)) are often used to test advances in the theory of electrolyte solutions because they are considered an ideal strong 2:1 electrolyte. However, there is evidence that some ... -
Molecular engineering binuclear copper catalysts for selective CO<inf>2</inf> reduction to C<inf>2</inf> products
(2024-06-01)Molecular copper catalysts serve as exemplary models for correlating the structure-reaction-mechanism relationship in the electrochemical CO2 reduction (eCO2R), owing to their adaptable environments surrounding the copper ... -
Synthesis of Sn doped and rice husk derived activated carbon surface coating NMC 811 through solution combustion method.
(2024-01-15)Nickel rich cathode material is widely used in lithium-ion batteries due to its high capacity, low cost, and environmentally friendly. However, high nickel content leads to capacity decay, poor rate capability, thermal and ... -
A recently formed ocean inside Saturn's moon Mimas.
(Nature Research, 2024-02-07)Moons potentially harbouring a global ocean are tending to become relatively common objects in the Solar System1. The presence of these long-lived global oceans is generally betrayed by surface modification owing to internal ... -
Probing the synergetic impacts of temperature modulation and lanthanide doping on [Sm<sup>3+</sup>-Eu<sup>3+</sup>-Tm<sup>3+</sup>]:CsPbI<inf>2.7</inf>Br<inf>0.3</inf> designed for advanced energy technologies
(2024-04-15)This is the first investigation of the triumvirate lanthanide doped novel perovskite host i.e. [Sm3+-Eu3+-Tm3+]:CsPbI2.7Br0.3 (SET:C-PVSK). Furthermore, this is also the first elucidation of using SET:C-PVSK in advanced ... -
Encapsulation with a complex of acidic/alkaline polysaccharide-whey protein isolate fibril bilayer microcapsules enhances the stability of β-carotene under acidic environments
(2024-01-01)Background: Recent studies have highlighted the potential of protein fibrils for the microencapsulation of lipophilic bioactive molecules. Given their biocompatible and biodegradable properties, as well as their enhanced ... -
Direct biological fixation provides a freshwater sink for N2O.
(Nature Research, 2023-10-25)Nitrous oxide (N2O) is a potent climate gas, with its strong warming potential and ozone-depleting properties both focusing research on N2O sources. Although a sink for N2O through biological fixation has been observed in ...