Now showing items 1-2 of 2

    • B-cell-specific checkpoint molecules that regulate anti-tumour immunity. 

      Bod, L; Kye, Y-C; Shi, J; Torlai Triglia, E; Schnell, A; Fessler, J; Ostrowski, SM; Von-Franque, MY; Kuchroo, JR; Barilla, RM (2023-07)
      The role of B cells in anti-tumour immunity is still debated and, accordingly, immunotherapies have focused on targeting T and natural killer cells to inhibit tumour growth1,2. Here, using high-throughput flow cytometry ...
    • Stepwise-edited, human melanoma models reveal mutations' effect on tumor and microenvironment. 

      Hodis, E; Torlai Triglia, E; Kwon, JYH; Biancalani, T; Zakka, LR; Parkar, S; Hütter, J-C; Buffoni, L; Delorey, TM; Phillips, D (2022-04-29)
      Establishing causal relationships between genetic alterations of human cancers and specific phenotypes of malignancy remains a challenge. We sequentially introduced mutations into healthy human melanocytes in up to five ...