Browsing Awaiting Allocation by Author "Capranico, G"
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Topoisomerase I poison-triggered immune gene activation is markedly reduced in human small-cell lung cancers by impairment of the cGAS/STING pathway.
Marinello, J; Arleo, A; Russo, M; Delcuratolo, M; Ciccarelli, F; Pommier, Y; Capranico, G (Cell Press, 2022-10-07)BACKGROUND: Current immunotherapy strategies have contrasting clinical results in human lung cancer patients as small-cell lung cancers (SCLC) often show features of immunological cold tumours. Topoisomerase 1 (TOP1) poisons ...