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Now showing items 115-134 of 247
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Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease.
(Springer Nature, 2024-04-08)One in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged symptoms termed long coronavirus disease (COVID), yet disease phenotypes and mechanisms are poorly understood1. Here we profiled 368 ... -
Less pain reported 5 years after cementless compared to cemented unicompartmental knee replacement: an analysis of pain, neuropathy, and co-morbidity scores
(Springer Science and Business Media LLC, 2023-11)<jats:title>Abstract</jats:title><jats:sec> <jats:title>Purpose</jats:title> <jats:p>To compare patient-reported pain scores and assess the influence of neuropathy and co-morbidity, on knee pain following cemented and ... -
Literature Review of BARD1 as a Cancer Predisposing Gene with a Focus on Breast and Ovarian Cancers.
(2020-07-27)Soon after the discovery of BRCA1 and BRCA2 over 20 years ago, it became apparent that not all hereditary breast and/or ovarian cancer syndrome families were explained by germline variants in these cancer predisposing ... -
Long-term feeder-free culture of human pancreatic progenitors on fibronectin or matrix-free polymer potentiates β cell differentiation.
(2022-05-10)With the aim of producing β cells for replacement therapies to treat diabetes, several protocols have been developed to differentiate human pluripotent stem cells to β cells via pancreatic progenitors. While in vivo ... -
Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study - PHOSP-COVID.
(European Respiratory Society (ERS), 2024-07-15)BACKGROUND: The long-term outcomes of COVID-19 hospitalisation in individuals with pre-existing airway diseases are unknown. METHODS: Adult participants hospitalised for confirmed or clinically suspected COVID-19 and ... -
The longevity and reversibility of quiescence in Schizosaccharomyces pombe are dependent upon the HIRA histone chaperone
(Taylor and Francis Group, 2023-08-27)Quiescence (G0) is a reversible non-dividing state that facilitates cellular survival in adverse conditions. Here, we demonstrate that the HIRA histone chaperone complex is required for the reversibility and longevity of ... -
Low Citrate Synthase Activity Is Associated with Glucose Intolerance and Lipotoxicity.
(Hindawi, 2019-03-03)Citrate synthase (CS) is a key mitochondrial enzyme. The aim of this study was to test the hypothesis that low CS activity impairs the metabolic health of mice fed a high fat diet (HFD) and promotes palmitate-induced ... -
Machine learning Sasakian and G<inf>2</inf> topology on contact Calabi-Yau 7-manifolds
(2024-03-01)We propose a machine learning approach to study topological quantities related to the Sasakian and G2-geometries of contact Calabi-Yau 7-manifolds. Specifically, we compute datasets for certain Sasakian Hodge numbers and ... -
Machine-learning dessins d’enfants: Explorations via modular and Seiberg–Witten curves
(2021-02-19)We apply machine-learning to the study of dessins d’enfants. Specifically, we investigate a class of dessins which reside at the intersection of the investigations of modular subgroups, Seiberg–Witten (SW) curves and ... -
A matched comparison of cementless unicompartmental and total knee replacement outcomes based on the National Joint Registry for England, Wales, Northern Ireland and the Isle of Man
<jats:p>Background and purpose: The main treatments for severe medial compartment knee arthritis are unicompartmental (UKR) and total knee replacement (TKR). UKRs have higher revision rates, particularly for aseptic ... -
A Matched Comparison of the Long-Term Outcomes of Cemented and Cementless Total Knee Replacements
(Ovid Technologies (Wolters Kluwer Health), 2021-12-15)<jats:sec> <jats:title>Background:</jats:title> <jats:p>Total knee replacements (TKRs) can be implanted with or without the use of cement. It is currently uncertain how cemented and cementless TKRs compare overall and in ... -
A matched comparison of the patient-reported outcome measures of 38,716 total and unicompartmental knee replacements: an analysis of linked data from the National Joint Registry of England, Northern Ireland and Isle of Man and England’s National PROM collection programme
(Medical Journals Sweden AB, 2021-11-02) -
A matched comparison of the patient-reported outcome measures of cemented and cementless total knee replacements, based on the National Joint Registry of England, Wales, Northern Ireland, and Isle of Man and England’s National PROM collection programme
<jats:p>Background and purpose — Total knee replacement (TKR) can be implanted with or without bone cement. It is currently unknown how the functional outcomes compare. Therefore, we compared the patient-reported outcome ... -
Methanolobus use unspecific methyltransferases to produce methane from dimethylsulphide in Baltic Sea sediments.
(2024-01-03)BACKGROUND: In anoxic coastal and marine sediments, degradation of methylated compounds is the major route to the production of methane, a powerful greenhouse gas. Dimethylsulphide (DMS) is the most abundant biogenic organic ... -
The Mid- to Long-Term Outcomes of the Lateral Domed Oxford Unicompartmental Knee Replacement: An Analysis From the National Joint Registry for England, Wales, Northern Ireland, and the Isle of Man.
(2021-01)BACKGROUND: Lateral unicompartmental knee replacement (UKR) is an alternative to total knee replacement for isolated lateral unicompartmental knee arthritis. The geometry and mechanics of the lateral compartment differ to ...