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Now showing items 100-119 of 247
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Identification of Pseudomonas aeruginosa exopolysaccharide Psl in biofilms using 3D OrbiSIMS
(AIP Publishing, 2023-05-31)Secondary ion mass spectrometry (SIMS) offers advantages over both liquid extraction mass spectrometry and matrix assisted laser desorption mass spectrometry in that it provides the direct in situ analysis of molecules and ... -
ImmunoCluster provides a computational framework for the nonspecialist to profile high-dimensional cytometry data.
(2021-04-30)High-dimensional cytometry is an innovative tool for immune monitoring in health and disease, and it has provided novel insight into the underlying biology as well as biomarkers for a variety of diseases. However, the ... -
Impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in patients with severe asthma.
(2023-12-25)BACKGROUND: There is little agreement on clinically useful criteria for identifying real-world responders to biologic treatments for asthma. OBJECTIVE: To investigate the impact of pre-biologic impairment on meeting ... -
Improved chromosome-level genome assembly of the Glanville fritillary butterfly (Melitaea cinxia) integrating Pacific Biosciences long reads and a high-density linkage map.
(2022-01-12)BACKGROUND: The Glanville fritillary (Melitaea cinxia) butterfly is a model system for metapopulation dynamics research in fragmented landscapes. Here, we provide a chromosome-level assembly of the butterfly's genome ... -
Increased fidelity of protein synthesis extends lifespan.
(Cell Press, 2021-09-14)Loss of proteostasis is a fundamental process driving aging. Proteostasis is affected by the accuracy of translation, yet the physiological consequence of having fewer protein synthesis errors during multi-cellular organismal ... -
Inferred representations behave like oscillators in dynamic Bayesian models of beat perception
(Elsevier, 2024-07-23)The human's capacity to perceptually entrain to an auditory rhythm has been repeatedly modeled as a dynamical system consisting of one or more forced oscillators. However, a more recent perspective, closely related to the ... -
Integrated care model for patients with functional somatic symptom disorder - a co-produced stakeholder exploration with recommendations for best practice.
(2024-06-03)BACKGROUND: Functional somatic symptoms (FFS) and bodily distress disorders are highly prevalent across all medical settings. Services for these patients are dispersed across the health care system with minimal conceptual ... -
An international comparison of competency-based orthopaedic curricula and minimum operative experience- Review article
(Ovid Technologies (Wolters Kluwer Health), 2021-10) -
International Variation in Severe Exacerbation Rates in Patients With Severe Asthma.
(2024-02-21)BACKGROUND: Exacerbation frequency strongly influences treatment choices in patients with severe asthma. RESEARCH QUESTION: What is the extent of the variability of exacerbations rate across countries and its implications ... -
Interplays of AMPK and TOR in Autophagy Regulation in Yeast.
(MDPI, 2023-02-04)Cells survey their environment and need to balance growth and anabolism with stress programmes and catabolism towards maximum cellular bioenergetics economy and survival. Nutrient-responsive pathways, such as the mechanistic ... -
Investigating the Role of Fe-Pyrrolic N4 Configuration in the Oxygen Reduction Reaction via Covalently Bound Porphyrin Functionalized Carbon Nanotubes
(Wiley, 2023-12-31)Atomically dispersed iron–nitrogen–carbon catalysts are promised, low-cost, and high-performance electrocatalysts for the Oxygen Reduction Reaction (ORR) in fuel cells. However, most Fe–N–C materials are produced via ... -
Is obesity more likely among children sharing a household with an older child with obesity? Cross-sectional study of linked National Child Measurement Programme data and electronic health records.
(2024-04-10)BACKGROUND/OBJECTIVES: We identified household members from electronic health records linked to National Child Measurement Programme (NCMP) data to estimate the likelihood of obesity among children living with an older ... -
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease.
(Springer Nature, 2024-04-08)One in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged symptoms termed long coronavirus disease (COVID), yet disease phenotypes and mechanisms are poorly understood1. Here we profiled 368 ... -
Less pain reported 5 years after cementless compared to cemented unicompartmental knee replacement: an analysis of pain, neuropathy, and co-morbidity scores
(Springer Science and Business Media LLC, 2023-11)<jats:title>Abstract</jats:title><jats:sec> <jats:title>Purpose</jats:title> <jats:p>To compare patient-reported pain scores and assess the influence of neuropathy and co-morbidity, on knee pain following cemented and ... -
Literature Review of BARD1 as a Cancer Predisposing Gene with a Focus on Breast and Ovarian Cancers.
(2020-07-27)Soon after the discovery of BRCA1 and BRCA2 over 20 years ago, it became apparent that not all hereditary breast and/or ovarian cancer syndrome families were explained by germline variants in these cancer predisposing ...