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Now showing items 85-104 of 247
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Genetic analyses of DNA repair pathway associated genes implicate new candidate cancer predisposing genes in ancestrally defined ovarian cancer cases
(Frontiers Media, 2023-03-08)Not all familial ovarian cancer (OC) cases are explained by pathogenic germline variants in known risk genes. A candidate gene approach involving DNA repair pathway genes was applied to identify rare recurring pathogenic ... -
The Genetic Analyses of French Canadians of Quebec Facilitate the Characterization of New Cancer Predisposing Genes Implicated in Hereditary Breast and/or Ovarian Cancer Syndrome Families
(MDPI, 2021-07-07)The French Canadian population of the province of Quebec has been recognized for its contribution to research in medical genetics, especially in defining the role of heritable pathogenic variants in cancer predisposing ... -
The Genetic and Molecular Analyses of RAD51C and RAD51D Identifies Rare Variants Implicated in Hereditary Ovarian Cancer from a Genetically Unique Population
(MDPI, 2022-04-30)To identify candidate variants in RAD51C and RAD51D ovarian cancer (OC) predisposing genes by investigating French Canadians (FC) exhibiting unique genetic architecture. Candidates were identified by whole exome sequencing ... -
Genome-wide screens in yeast models towards understanding chronological lifespan regulation.
(Oxford University Press, 2021-03-17)Cellular models such as yeasts are a driving force in biogerontology studies. Their simpler genome, short lifespans and vast genetic and genomics resources make them ideal to characterise pro-ageing and anti-ageing genes ... -
The genomic footprint of social stratification in admixing American populations.
(2023-12-01)Cultural and socioeconomic differences stratify human societies and shape their genetic structure beyond the sole effect of geography. Despite mating being limited by sociocultural stratification, most demographic models ... -
Hagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences.
(2024-03)Polyploidy or whole-genome duplication (WGD) is a major event that drastically reshapes genome architecture and is often assumed to be causally associated with organismal innovations and radiations. The 2R hypothesis ... -
Heartbeat counting accuracy is enhanced in blind individuals
(American Psychological Association, 2023-03-23)Blind individuals have superior abilities to perform perceptual tasks that rely on exteroceptive information, since visual deprivation is associated with heightened cross-modal plasticity. However, it is unknown whether ... -
High Mobility Amorphous Polymer-Based 3D Stacked Pseudo Logic Circuits through Precision Printing
(Wiley, 2024-05-01)Direct printing of conjugated polymer thin-film transistors enables the fabrication of deformable devices with low cost, high throughput, and large area. However, a relatively poor device performance of printed devices ... -
Hilbert series, machine learning, and applications to physics
(2022-04-10)We describe how simple machine learning methods successfully predict geometric properties from Hilbert series (HS). Regressors predict embedding weights in projective space to ∼1 mean absolute error, whilst classifiers ... -
How long does an elbow replacement last? A systematic review and meta-analysis of case-series and national registry reports with more than 10 years of follow-up
<jats:p>Background and purpose: This study aims to determine, for the first time, generalizable data on the longevity and long-term function of elbow replacements.Methods: In this systematic review and meta-analysis, we ... -
How to use the HOME Core Outcome Set for atopic dermatitis trials - a users' guide.
(2023-12-20)The Harmonizing Outcome Measures for Eczema (HOME) initiative has agreed upon the core outcome set for use in atopic dermatitis (AD) clinical trials, but additional guidance is needed to maximise uptake of the core set. ... -
Hydrogel-based standards for single and multiphoton imaging at depth
(SPIE, the international society for optics and photonics, 2024-03-13) -
Identification of Pseudomonas aeruginosa exopolysaccharide Psl in biofilms using 3D OrbiSIMS
(AIP Publishing, 2023-05-31)Secondary ion mass spectrometry (SIMS) offers advantages over both liquid extraction mass spectrometry and matrix assisted laser desorption mass spectrometry in that it provides the direct in situ analysis of molecules and ... -
ImmunoCluster provides a computational framework for the nonspecialist to profile high-dimensional cytometry data.
(2021-04-30)High-dimensional cytometry is an innovative tool for immune monitoring in health and disease, and it has provided novel insight into the underlying biology as well as biomarkers for a variety of diseases. However, the ... -
Impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in patients with severe asthma.
(2023-12-25)BACKGROUND: There is little agreement on clinically useful criteria for identifying real-world responders to biologic treatments for asthma. OBJECTIVE: To investigate the impact of pre-biologic impairment on meeting ... -
Improved chromosome-level genome assembly of the Glanville fritillary butterfly (Melitaea cinxia) integrating Pacific Biosciences long reads and a high-density linkage map.
(2022-01-12)BACKGROUND: The Glanville fritillary (Melitaea cinxia) butterfly is a model system for metapopulation dynamics research in fragmented landscapes. Here, we provide a chromosome-level assembly of the butterfly's genome ...