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Now showing items 77-96 of 247
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Facile One-Pot Nanoproteomics for Label-Free Proteome Profiling of 50-1000 Mammalian Cells
(American Chemical Society, 2021-08-05) -
Ferroelectric anomaly of perovskite layer structured Pb<sup>2+</sup>-doped Sr<inf>2</inf>Nb<inf>2</inf>O<inf>7</inf> ceramics
(2024-01-01)The spontaneous polarization of perovskite layer structured Sr2Nb2O7 ferroelectrics (FEs) is originated from mainly the oxygen octahedral rotations and partially the displacement of Sr2+ ions. However, there is FE anomaly ... -
A fluorogenic, peptide-based probe for the detection of Cathepsin D in macrophages.
(2023-11-02)Cathepsin D is a protease that is an effector in the immune response of macrophages, yet to date, only a limited number of probes have been developed for its detection. Herein, we report a water soluble, highly sensitive, ... -
Fluorophore-Tagged Poly-Lysine RAFT Agents: Controlled Synthesis of Trackable Cell-Penetrating Peptide-Polymers.
(2023-09-11)The conjugation of a fluorophore and a variety of cell-penetrating peptides onto a RAFT agent allowed for the synthesis of polymers of defined sizes with quantifiable cell-uptake. Each peptide-RAFT agent was used to ... -
Full spectrum fluorescence lifetime imaging with 0.5 nm spectral and 50 ps temporal resolution.
(2021-11-16)The use of optical techniques to interrogate wide ranging samples from semiconductors to biological tissue for rapid analysis and diagnostics has gained wide adoption over the past decades. The desire to collect ever more ... -
A functionally impaired missense variant identified in French Canadian families implicates FANCI as a candidate ovarian cancer-predisposing gene
(BMC, 2021-12-03)BACKGROUND: Familial ovarian cancer (OC) cases not harbouring pathogenic variants in either of the BRCA1 and BRCA2 OC-predisposing genes, which function in homologous recombination (HR) of DNA, could involve pathogenic ... -
Genetic analyses of DNA repair pathway associated genes implicate new candidate cancer predisposing genes in ancestrally defined ovarian cancer cases
(Frontiers Media, 2023-03-08)Not all familial ovarian cancer (OC) cases are explained by pathogenic germline variants in known risk genes. A candidate gene approach involving DNA repair pathway genes was applied to identify rare recurring pathogenic ... -
The Genetic Analyses of French Canadians of Quebec Facilitate the Characterization of New Cancer Predisposing Genes Implicated in Hereditary Breast and/or Ovarian Cancer Syndrome Families
(MDPI, 2021-07-07)The French Canadian population of the province of Quebec has been recognized for its contribution to research in medical genetics, especially in defining the role of heritable pathogenic variants in cancer predisposing ... -
The Genetic and Molecular Analyses of RAD51C and RAD51D Identifies Rare Variants Implicated in Hereditary Ovarian Cancer from a Genetically Unique Population
(MDPI, 2022-04-30)To identify candidate variants in RAD51C and RAD51D ovarian cancer (OC) predisposing genes by investigating French Canadians (FC) exhibiting unique genetic architecture. Candidates were identified by whole exome sequencing ... -
Genome-wide screens in yeast models towards understanding chronological lifespan regulation.
(Oxford University Press, 2021-03-17)Cellular models such as yeasts are a driving force in biogerontology studies. Their simpler genome, short lifespans and vast genetic and genomics resources make them ideal to characterise pro-ageing and anti-ageing genes ... -
The genomic footprint of social stratification in admixing American populations.
(2023-12-01)Cultural and socioeconomic differences stratify human societies and shape their genetic structure beyond the sole effect of geography. Despite mating being limited by sociocultural stratification, most demographic models ... -
Hagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences.
(2024-03)Polyploidy or whole-genome duplication (WGD) is a major event that drastically reshapes genome architecture and is often assumed to be causally associated with organismal innovations and radiations. The 2R hypothesis ... -
Heartbeat counting accuracy is enhanced in blind individuals
(American Psychological Association, 2023-03-23)Blind individuals have superior abilities to perform perceptual tasks that rely on exteroceptive information, since visual deprivation is associated with heightened cross-modal plasticity. However, it is unknown whether ... -
High Mobility Amorphous Polymer-Based 3D Stacked Pseudo Logic Circuits through Precision Printing
(Wiley, 2024-05-01)Direct printing of conjugated polymer thin-film transistors enables the fabrication of deformable devices with low cost, high throughput, and large area. However, a relatively poor device performance of printed devices ... -
Hilbert series, machine learning, and applications to physics
(2022-04-10)We describe how simple machine learning methods successfully predict geometric properties from Hilbert series (HS). Regressors predict embedding weights in projective space to ∼1 mean absolute error, whilst classifiers ...