Browsing Awaiting Allocation by Title
Now showing items 154-173 of 247
-
New Calabi-Yau Manifolds from Genetic Algorithms
(2023-06-09) -
New Calabi–Yau manifolds from genetic algorithms
(2024-03-01)Calabi–Yau manifolds can be obtained as hypersurfaces in toric varieties built from reflexive polytopes. We generate reflexive polytopes in various dimensions using a genetic algorithm. As a proof of principle, we demonstrate ... -
NGTS discovery of a highly inflated Saturn-mass planet and a highly irradiated hot Jupiter: NGTS-26 b and NGTS-27 b
(2024-04-01)We report the discovery of two new transiting giant exoplanets NGTS-26 b and NGTS-27 b by the Next Generation Transit Survey (NGTS). NGTS-26 b orbits around a G6-type main sequence star every 4.52 days. It has a mass of ... -
A niche-mimicking polymer hydrogel-based approach to identify molecular targets for tackling human pancreatic cancer stem cells.
(2023-09-27)BACKGROUND: Pancreatic adenocarcinoma (PAAD) is one of the most fatal human cancers, but effective therapies remain to be established. Cancer stem cells (CSCs) are highly resistant to anti-cancer drugs and a deeper ... -
Non-calcified plaque-based coronary stenosis grading in contrast enhanced CT
(Elsevier, 2024-05-22)Background: The high mortality rate associated with coronary heart disease has led to state-of-the-art non-invasive methods for cardiac diagnosis including computed tomography and magnetic resonance imaging. However, ... -
Normal Somatic Mutations in Cancer Transformation.
(2021-02-08)Gene alterations play a prominent role in driving cancer initiation and progression. However, the genetic events that occur in normal cells prior to tumorigenesis are still unknown. Recent studies have started to map somatic ... -
Nutrient-Response Pathways in Healthspan and Lifespan Regulation.
(MDPI, 2022-05-06)Cellular, small invertebrate and vertebrate models are a driving force in biogerontology studies. Using various models, such as yeasts, appropriate tissue culture cells, Drosophila, the nematode Caenorhabditis elegans and ... -
Object detection algorithms to identify skeletal components in carbonate cores
(2024-09-01)Identification of constituent grains in carbonate rocks requires specialist experience. A carbonate sedimentologist must be able to distinguish between skeletal grains that change through geological ages, preserved in ... -
Observational and genetic associations between cardiorespiratory fitness and cancer: a UK Biobank and international consortia study
(Springer Nature, 2023-12-06)BACKGROUND: The association of fitness with cancer risk is not clear. METHODS: We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for risk of lung, colorectal, ... -
Oncogenic c-Myc induces replication stress by increasing cohesins chromatin occupancy in a CTCF-dependent manner.
(2024-02-21)Oncogene-induced replication stress is a crucial driver of genomic instability and one of the key events contributing to the onset and evolution of cancer. Despite its critical role in cancer, the mechanisms that generate ... -
Optical Detection of Distal Lung Enzyme Activity in Human Inflammatory Lung Disease.
(2021)Objective and Impact Statement. There is a need to develop platforms delineating inflammatory biology of the distal human lung. We describe a platform technology approach to detect in situ enzyme activity and observe drug ... -
Paraneoplastic cast nephropathy associated with malignant prolactinoma: A case report and literature review.
(2022-07)Malignant prolactinomas are very rare and are diagnosed when a prolactin-producing pituitary adenoma has metastasized. We report on a 54-year-old man with a history of macroprolactinoma transforming into a pituitary carcinoma ... -
Peptide probes for proteases - innovations and applications for monitoring proteolytic activity.
(2022-03-21)Proteases are excellent biomarkers for a variety of diseases, offer multiple opportunities for diagnostic applications and are valuable targets for therapy. From a chemistry-based perspective this review discusses and ... -
Phase separation on microtubules: from droplet formation to cellular function?
(2024-01)Microtubules are cytoskeletal polymers that play important roles in numerous cellular processes, ranging from the control of cell shape and polarity to cell division and intracellular transport. Many of these roles rely ... -
Physiotherapist-led exercise versus usual care (waiting-list) control for patients awaiting rotator cuff repair surgery: A pilot randomised controlled trial (POWER).
(2023-11)BACKGROUND: Once a decision to undergo rotator cuff repair surgery is made, patients are placed on the waiting list. It can take weeks or months to receive surgery. There has been a call to move from waiting lists to ... -
Phyto-mediated CuO–Sb<inf>2</inf>O<inf>3</inf> nanocomposite supported on Ni foam as a proficient dual-functional supercapacitor electrode and overall water splitting electrocatalyst
(2023-01-01)Owing to the higher global energy needs through cleaner sources the present study manifests a modified and ecofriendly method for the fabrication of CuO–Sb2O3-based electrode for electrochemical experiments. The aqueous ... -
Polygenic Risk and the Course of Attention-Deficit/Hyperactivity Disorder From Childhood to Young Adulthood: Findings From a Nationally Representative Cohort
(Elsevier, 2021-01-10)Objective To understand whether genetic risk for attention-deficit/hyperactivity disorder (ADHD) is associated with the course of the disorder across childhood and into young adulthood. Method Participants were from ...