Browsing Cell and Molecular Biology by Subject "Mutation"
Now showing items 1-3 of 3
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Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population.
(2012-07-15)Benznidazole is the frontline drug used against Trypanosoma cruzi, the causative agent of Chagas disease. However, treatment failures are often reported. Here, we demonstrate that independently acquired mutations in the ... -
Estimating the distribution of selection coefficients from phylogenetic data using sitewise mutation-selection models.
(2012-03)Estimation of the distribution of selection coefficients of mutations is a long-standing issue in molecular evolution. In addition to population-based methods, the distribution can be estimated from DNA sequence data by ...