Browsing Cell and Molecular Biology by Subject "Chagas disease"

Now showing items 1-2 of 2

    • Nitrotriazole-based acetamides and propanamides with broad spectrum antitrypanosomal activity. 

      Papadopoulou, MV; Bloomer, WD; Rosenzweig, HS; Wilkinson, SR; Szular, J; Kaiser, M (2016-11-10)
      3-Nitro-1H-1,2,4-triazole-based acetamides bearing a biphenyl- or a phenoxyphenyl moiety have shown remarkable antichagasic activity both in vitro and in an acute murine model, as well as substantial in vitro antileishmanial ...

    • Novel 3-nitrotriazole-based amides and carbinols as bifunctional anti-Chagasic agents. 

      Papadopoulou, MV; Bloomer, WD; Lepesheva, GI; Rosenzweig, HS; Kaiser, M; Aguilera-Venegas, B; WILKINSON, SR; Chatelain, E; Ioset, JR (American Chemical Society, 2015-01-23)
      3-Nitro-1H-1,2,4-triazole-based amides with a linear, rigid core and 3-nitrotriazole-based fluconazole analogs were synthesized as dual functioning antitrypanosomal agents. Such compounds are excellent substrates for type ...