Browsing Cell and Molecular Biology by Author "Leung, HY"
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Identification of novel androgen-regulated pathways and mRNA isoforms through genome-wide exon-specific profiling of the LNCaP transcriptome.
Rajan, P; Dalgliesh, C; Carling, PJ; Buist, T; Zhang, C; Grellscheid, SN; Armstrong, K; Stockley, J; Simillion, C; Gaughan, L (2011)Androgens drive the onset and progression of prostate cancer (PCa) by modulating androgen receptor (AR) transcriptional activity. Although several microarray-based studies have identified androgen-regulated genes, here we ... -
Proteomic identification of heterogeneous nuclear ribonucleoprotein L as a novel component of SLM/Sam68 Nuclear Bodies.
Rajan, P; Dalgliesh, C; Bourgeois, CF; Heiner, M; Emami, K; Clark, EL; Bindereif, A; Stevenin, J; Robson, CN; Leung, HY (2009-11-13)BACKGROUND: Active pre-mRNA splicing occurs co-transcriptionally, and takes place throughout the nucleoplasm of eukaryotic cells. Splicing decisions are controlled by networks of nuclear RNA-binding proteins and their ...